{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:50:45Z","timestamp":1781736645996,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cerebral oedema is a major pathological change of acute carbon monoxide (CO) poisoning, the pathogenesis of which is still unclear. In the aquaporin (AQP) water channel family, AQP1 and AQP4 play critical roles in the progress of cerebral oedema of various neuropathological events. However, their functions in CO poisoning have not been demonstrated. In this study, we investigated the expressions of AQPs and associated mechanisms of brain injury in an acute CO poisoning rat model. Compared with the control injected intraperitoneally with equal volume of air, the dry weight\/wet weight (DW\/WW) ratio of brain water content, levels of AQP1, AQP4, phosph\u2010p38 mitogen\u2010activated protein kinase (p\u2010p38 MAPK) and astrocyte marker, glial fibrillary acidic protein (GFAP) in the frontal cortex and hippocampal CA1 of acute CO poisoning group significantly increased at 6, 12, 24\u00a0hours after CO injection. Intracerebroventricular injection with a p38 MAPK inhibitor, SB203580 (200\u00a0\u00b5mol\/L\/kg\/d), before CO injection reduced water content in the brain tissues and significantly decreased levels of AQP1, AQP4, p\u2010p38 MAPK and GFAP. Therefore, our study showed that the overexpressions of AQP1 and AQP4 were involved in the development of CO poisoning\u2010induced cerebral oedema, which could be attenuated by inhibition of p\u2010p38 MAPK signalling. Manipulation of AQPs and p38 MAPK may be a new therapeutic strategy for acute CO poisoning.<\/jats:p>","DOI":"10.1111\/bcpt.13247","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T22:37:51Z","timestamp":1557268671000},"page":"394-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Involvement of p38 mitogen\u2010activated protein kinase in altered expressions of AQP1 and AQP4 after carbon monoxide poisoning in rat astrocytes"],"prefix":"10.1111","volume":"125","author":[{"given":"Jinlan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Enshi Tujia and Miao Autonomous Prefecture Center Hospital Enshi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurology Enshi Tujia and Miao Autonomous Prefecture Center Hospital Enshi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuke","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Neurology Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Enshi Tujia and Miao Autonomous Prefecture Center Hospital Enshi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Enshi Tujia and Miao Autonomous Prefecture Center Hospital Enshi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201503-0609OC"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2015.05.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201606-1275CI"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491212700504"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534582306289730"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704101082"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.899499"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-015-9618-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2015.48.6.237"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15617172"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.1899"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.06.023"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113686"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2007.00774.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2015.47"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.06.033"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15623290"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.15.7275"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-211-30714-1_82"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-014-1374-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2014.07.014"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155414537495"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.11.016"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0558-4"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3468"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101413"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091415605486"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/72256"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2012.00308.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0120-06.2006"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20916"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21023"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209980200"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304368200"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13059"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(98)00040-3"},{"key":"e_1_2_7_38_1","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2007"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16059949"},{"key":"e_1_2_7_40_1","doi-asserted-by":"crossref","first-page":"e0129121","DOI":"10.1371\/journal.pone.0129121","article-title":"Risk factors for non\u2010occupational carbon monoxide poisoning: Anshan Prefecture, Liaoning Province, China, 2011\u20132012","volume":"10","author":"Lu Q","year":"2015","journal-title":"PLoS ONE"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5839762"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22210"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-016-4271-4"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90024-4"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1995.1099"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00116"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.08.010"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70055-8"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.07.084"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2430"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24308"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.13247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.13247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcpt.13247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.13247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T06:02:01Z","timestamp":1694325721000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.13247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,3]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/bcpt.13247"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.13247","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,3]]},"assertion":[{"value":"2019-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}