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This prospective case\u2010control study included 28 men with recently diagnosed type 2 diabetes mellitus and mild or moderate hyperprolactinaemia, 14 of whom had low testosterone levels, while in the remaining 14 ones' testosterone levels were within the reference range. All participants received metformin (2.55\u20103\u00a0g daily) for the following 4\u00a0months. Circulating levels of glucose, insulin, prolactin, testosterone, oestradiol, gonadotropins, sex hormone\u2010binding globulin adrenocorticotropic hormone, insulin\u2010like growth factor\u20101, thyrotropin and free\u00a0thyroid\u00a0hormones were measured at the beginning and at the end of the study. Although metformin\u00a0reduced plasma glucose levels and improved insulin sensitivity in both groups, this effect was stronger in participants with low testosterone levels. Only in patients with abnormally low testosterone levels, the drug decreased prolactin levels. This effect, which was accompanied by an increase in luteinizing hormone levels, was inversely correlated with baseline testosterone and calculated free testosterone levels, and positively with treatment\u2010induced improvement in insulin sensitivity. In both treatment groups, metformin produced a neutral effect on plasma levels of the remaining hormones. The obtained results suggest that endogenous testosterone may attenuate the impact of metformin on lactotropic cells.<\/jats:p>","DOI":"10.1111\/bcpt.13307","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T11:58:47Z","timestamp":1566043127000},"page":"110-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Endogenous testosterone determines metformin action on prolactin levels in hyperprolactinaemic men: A pilot study"],"prefix":"10.1111","volume":"126","author":[{"given":"Robert","family":"Krysiak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Witold","family":"Szkr\u00f3bka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogus\u0142aw","family":"Okopie\u0144","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5603\/EP.2017.0050"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986707780597943"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(10)70357-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.373"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0584-0006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-014-0428-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0501"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2016.01.015"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-122224"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2016.07.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1322"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2677"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1480325"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-3-1405"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-99-6-1482"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101403"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2006.09.038"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13059"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.04.008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1258\/000456306778520115"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02739938"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12996"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.110.087023"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.12.005"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.03.014"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(87)90150-6"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1297994"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2513"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/13685538.2013.805319"}],"container-title":["Basic &amp; 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