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Ageing evokes a number of functional, pharmacological and morphological changes in the vasculature, accompanied by a progressive failure of protective and homeostatic mechanisms, resulting in target organ damage. Impaired vasomotor, proliferation, migration, antithrombotic and anti\u2010inflammatory function in both the endothelial and vascular smooth muscle cells are parts of the vascular ageing phenotype. The endothelium regulates these functions by the release of a wide variety of active molecules including endothelium\u2010derived relaxing factors such as nitric oxide, prostacyclin (PGI<jats:sub>2<\/jats:sub>) and endothelium\u2010derived hyperpolarization (EDH). During ageing, a functional decay of the nitric oxide pathway takes place. Nitric oxide signals to VSMC and other important cell types for vascular homeostasis through the second messenger cyclic guanosine monophosphate (cGMP). Maintenance of proper cGMP levels is an important goal in sustainment of proper vascular function during ageing. For this purpose, different components can be targeted in this signalling system, and among them, phosphodiesterase\u20101 (PDE1) and soluble guanylate cyclase (sGC) are crucial. This review focuses on the role of PDE1 and sGC in conditions that are relevant for vascular ageing.<\/jats:p>","DOI":"10.1111\/bcpt.13319","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T07:24:27Z","timestamp":1567927467000},"page":"67-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The importance of the nitric oxide\u2010cGMP pathway in age\u2010related cardiovascular disease: Focus on phosphodiesterase\u20101 and soluble guanylate cyclase"],"prefix":"10.1111","volume":"127","author":[{"given":"Keivan","family":"Golshiri","sequence":"first","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology Department of Internal Medicine Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Ataei Ataabadi","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology Department of Internal Medicine Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana C.","family":"Portilla Fernandez","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology Department of Internal Medicine Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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