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Aryl hydrocarbon receptor (AhR), a ligand\u2010dependent transcription factor, has been shown to regulate the differentiation, activation and apoptosis of various cells involved in rheumatoid arthritis. The ligands of AhR such as tetrachlorodibenzo\u2010p\u2010dioxin, benzo[a]pyrene and 3,3\u2032\u2010diindolylmetheane are able to inhibit osteoclastogenesis and attenuate arthritis in mice. However, the long\u2010term use of these compounds is associated with severe side effects, which limit their use as therapeutic agents in animals or humans. There is an urgent need to search for new AhR ligands that are effective and safe. 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