{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:52:26Z","timestamp":1783075946129,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is evidence that the antipsychotic drug perazine is an inhibitor of CYP2D6. This study aimed at evaluating its effect on CYP2D6 and CYP2C19 activities in submitting psychiatric patients to phenotyping with dextromethorphan and mephenytoin, respectively, substrates of these enzymes, before and during a treatment with perazine. A total of 31 patients were phenotyped with dextromethorphan (CYP2D6) and mephenytoin (CYP2C19) before and after a 2\u2010week treatment with 450\u00a0\u00b1\u00a051\u00a0mg\/day (mean\u00a0\u00b1\u00a0sd) perazine. At baseline, five patients appeared to be poor metabolizers (PM) of dextromethorphan and two patients of mephenytoin. The metabolic ratio (MR) of dextromethorphan\/dextrorphan as determined in collected urine increased significantly (Wilcoxon; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) from baseline (0.39\u00a0\u00b1\u00a01.38 [mean\u00a0\u00b1\u00a0sd]) till day 14 (1.46\u00a0\u00b1\u00a02.22). In 19 out of 26 extensive metabolizers (EM) of dextromethorphan, the phenotype changed from EM to PM. This suggests an almost complete inhibition of CYP2D6 by perazine and\/or its metabolites. On the other hand, perazine (or some of its metabolites) did seemingly not inhibit CYP2C19. In conclusion, this study suggests that in patients treated with perazine and co\u2010medicated with CYP2D6 substrates, there could be an increased risk of adverse effects as a consequence of a pharmacokinetic interaction.<\/jats:p>","DOI":"10.1111\/bcpt.13373","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T08:42:51Z","timestamp":1575880971000},"page":"444-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of perazine on the CYP2D6 and CYP2C19 phenotypes as measured by the dextromethorphan and mephenytoin tests in psychiatric patients"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6253-5225","authenticated-orcid":false,"given":"Pierre","family":"Baumann","sequence":"first","affiliation":[{"name":"Department of Psychiatry (DP\u2010CHUV) University of Lausanne Prilly\u2010Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin B.","family":"Eap","sequence":"additional","affiliation":[{"name":"Unit of Pharmacogenetics and Clinical Psychopharmacology Centre for Psychiatric Neuroscience Department of Psychiatry Lausanne University Hospital University of Lausanne Prilly Switzerland"},{"name":"Center for Research and Innovation in Clinical Pharmaceutical Sciences University of Lausanne Prilly\u2010Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Gastpar","sequence":"additional","affiliation":[{"name":"Private Practice Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Perazine for schizophrenia (Review)","volume":"1","author":"Leucht S","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(03)00105-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000489"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13255"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527630905.ch11"},{"issue":"5","key":"e_1_2_6_7_1","first-page":"442","article-title":"Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response","volume":"9","author":"Kirchheiner J","year":"2004","journal-title":"MolPsychiatry"},{"issue":"11","key":"e_1_2_6_8_1","first-page":"1514","article-title":"Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CYP2D6 and CYP3A activities?","volume":"29","author":"Yu A","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(88)90146-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.041210"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2004.03.021"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13059"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39043"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200004000-00012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199202000-00001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200106000-00008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(86)90307-0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2001.00299.x"},{"issue":"1","key":"e_1_2_6_19_1","first-page":"9","article-title":"Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: update 2017","volume":"51","author":"Hiemke C","year":"2018","journal-title":"Pharmacopsychiatry"},{"key":"e_1_2_6_20_1","first-page":"201","article-title":"Stoffwechsel und Ausscheidung des Neuroleptikums Perazin bei gesunden Versuchspersonen","volume":"16","author":"Schley J","year":"1981","journal-title":"IntPharmacopsychiat"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00181950"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1019491"}],"container-title":["Basic &amp; 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