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We performed a historical cohort study of patients with a first\u2010time HF diagnosis from 1997 to 2015, identified in the Danish National Patient Registry. Dispensed pharmacological treatment included angiotensin\u2010converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), beta\u2010blockers, mineralocorticoid receptor blockers (MRAs), digoxin and diuretics. Furthermore, we estimated the proportion of patients receiving the recommended target dosages 1\u00a0year after the diagnosis. The utilisation increased and correlated with publication of landmark studies, and among patients diagnosed in 2015, approximately two of three received ACEI\/ARB and beta\u2010blocker, respectively. Less than half of the patients redeeming prescriptions for ACEIs, ARBs, beta\u2010blockers or MRAs received the recommended target dosages. The utilisation of pharmacological therapy for HF appears to be correlated with the publications of landmark Phase III clinical trials. However, a high proportion of patients do not receive the recommended target dosages. Despite improvements over time, a substantial gap appears to remain between guideline recommendations and pharmacological therapy in routine care.<\/jats:p>","DOI":"10.1111\/bcpt.13392","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T14:39:50Z","timestamp":1580481590000},"page":"30-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Twenty\u2010year time trends in use of evidence\u2010based heart failure drug therapy in Denmark"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0558-8483","authenticated-orcid":false,"given":"Nicklas","family":"Vinter","sequence":"first","affiliation":[{"name":"Diagnostic Centre Silkeborg Regional Hospital University Research Clinic for Innovative Patient Pathways Silkeborg Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Danish Center for Clinical Health Services Research Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Center for Clinical Health Services Research Department of Clinical Medicine Aalborg University Aalborg Denmark"},{"name":"Aalborg Thrombosis Research Unit Department of Clinical Medicine Faculty of Health Aalborg University and Aalborg University Hospital Aalborg Denmark"},{"name":"Unit of Clinical Biostatistics Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming","family":"Skj\u00f8th","sequence":"additional","affiliation":[{"name":"Aalborg Thrombosis Research Unit Department of Clinical Medicine Faculty of Health Aalborg University and Aalborg University Hospital Aalborg Denmark"},{"name":"Unit of Clinical Biostatistics Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben Bjerregaard","family":"Larsen","sequence":"additional","affiliation":[{"name":"Aalborg Thrombosis Research Unit Department of Clinical Medicine Faculty of Health Aalborg University and Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Frost","sequence":"additional","affiliation":[{"name":"Diagnostic Centre Silkeborg Regional Hospital University Research Clinic for Innovative Patient Pathways Silkeborg Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren Paaske","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Danish Center for Clinical Health Services Research Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2783"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn309"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs104"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi204"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015339"},{"key":"e_1_2_7_9_1","first-page":"741","article-title":"Guidelines for the diagnosis of heart failure. 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