{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:39:15Z","timestamp":1787315955751,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Clozapine is an effective antipsychotic drug for treatment\u2010resistant schizophrenia. Sertraline is a widely prescribed antidepressant and often concomitantly applied to address negative symptoms or depression. However, data on interactions between clozapine and sertraline are inconsistent. The aim of our study was to evaluate pharmacokinetic interactions between clozapine and sertraline analysing a therapeutic drug monitoring database of 1644 clozapine\u2010medicated patients. We compared four groups: non\u2010smokers (n\u00a0=\u00a0250) and smokers (n\u00a0=\u00a0326) with co\u2010medication without known effects on cytochrome P450 and without sertraline, and non\u2010smokers (n\u00a0=\u00a018) and smokers (n\u00a0=\u00a017) with sertraline co\u2010medication. Measured and dose\u2010corrected concentrations (C\/D) of clozapine were compared between the groups using non\u2010parametrical tests with a significance level of 0.05. Post hoc analyses included pairwise comparisons to account for smoking status. Although we detected significant differences for clozapine levels and C\/D values between study groups (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001 for Kruskal\u2010Wallis test in both cases), post hoc analyses revealed no differences for concentrations and C\/D values of clozapine (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&gt;\u00a0.05 for Mann\u2010Whitney\n                    <jats:italic>U<\/jats:italic>\n                    test in both cases). A negative correlation between the sertraline dose and the clozapine concentration was found in non\u2010smokers (Spearman's rank correlation,\n                    <jats:italic>rs<\/jats:italic>\n                    \u00a0=\u00a0\u22120.535,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.048). A potential pharmacokinetic interaction between clozapine and a standard therapeutic sertraline dose seems to be of minor clinical importance.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.13421","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T01:24:44Z","timestamp":1587345884000},"page":"303-308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacokinetic interactions between clozapine and sertraline in smokers and non\u2010smokers"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-8458","authenticated-orcid":false,"given":"Maxim","family":"Kuzin","sequence":"first","affiliation":[{"name":"Psychiatric and Psychotherapeutic Private Clinic Clienia Schl\u00f6ssli Academic Teaching Hospital of the University of Zurich Oetwil am See Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-4117","authenticated-orcid":false,"given":"Georgios","family":"Schoretsanitis","sequence":"additional","affiliation":[{"name":"Northwell Health Psychiatry Research The Zucker Hillside Hospital Glen Oaks NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard","family":"Haen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Clinical Pharmacology University of Regensburg Regensburg Germany"},{"name":"Department of Pharmacology and Toxicology University of Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Ridders","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Clinical Pharmacology University of Regensburg Regensburg Germany"},{"name":"Department of Pharmacology and Toxicology University of Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Hiemke","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy and Institute of Clinical Chemistry and Laboratory Medicine University Medical Center of Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Gr\u00fcnder","sequence":"additional","affiliation":[{"name":"Department of Molecular Neuroimaging Medical Faculty Mannheim Central Institute of Mental Health University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Paulzen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University Aachen Germany"},{"name":"JARA \u2013 Translational Brain Medicine J\u00fclich Germany"},{"name":"Alexianer Hospital Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14r09204"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12854"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.0624"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.4320"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00205-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033362"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-7006(06)76153-X"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0706743717718167"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"9","article-title":"Consensus guidelines for therapeutic drug monitoring in 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