{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:54:43Z","timestamp":1769014483335,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["P25\/1LF"],"award-info":[{"award-number":["P25\/1LF"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["P29\/1LF"],"award-info":[{"award-number":["P29\/1LF"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osmium tetroxide is a strong oxidizing agent used in electron microscopy. Eye exposure may cause severe burns, and after inhalation or ingestion damage to the respiratory or gastrointestinal tract occurs. Exposure to osmium and its compounds is extremely rare. We present a case of a 32\u2010year\u2010old female stained by 9\u00a0mL of 2% osmium tetroxide in acetone during an accident in the laboratory, with rare dermal and ocular findings. Due to lack of data in toxicological databases and the absence of antidote, the therapy was symptomatic. Osmium was detected in serum 19\u00a0hours later (0.22\u00a0\u03bcg\/L) and in urine during the 15\u2010hour collection (three samples\u20147.05, 1.65 and 8.45\u00a0\u03bcg\/L). In blood serum on admission, after 1 and 2\u00a0days after exposure, the levels of iron (28.2, 39.8 and 50.5\u00a0\u03bcmol\/L; reference range 5.8\u201034.5\u00a0\u03bcmol\/L) and transferrin receptor\/ferritine were elevated. To our knowledge, this is the first paper documenting a significant absorption from the skin and potentially from the eye conjunctiva, based on serum and urine analysis. The relationship between increased iron in blood and exposure has not been described yet, and the mechanism remains unknown. The patient is being followed up for the unknown long\u2010term effects.<\/jats:p>","DOI":"10.1111\/bcpt.13450","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T08:34:13Z","timestamp":1591864453000},"page":"429-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Osmium absorption after osmium tetroxide skin and eye exposure"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3482-0878","authenticated-orcid":false,"given":"Natalie","family":"Friedova","sequence":"first","affiliation":[{"name":"Internal Department Third Faculty of Medicine Charles University Thomayer Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Pelclova","sequence":"additional","affiliation":[{"name":"Toxicological Information Centre Department of Occupational Medicine First Faculty of Medicine Charles University General University Hospital Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7864-6245","authenticated-orcid":false,"given":"Nikola","family":"Obertova","sequence":"additional","affiliation":[{"name":"Toxicological Information Centre Department of Occupational Medicine First Faculty of Medicine Charles University General University Hospital Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Lach","sequence":"additional","affiliation":[{"name":"Institute of Public Health Ostrava Ostrava Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Kesslerova","sequence":"additional","affiliation":[{"name":"Ophthalmological Department Thomayer Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Kohout","sequence":"additional","affiliation":[{"name":"Internal Department Third Faculty of Medicine Charles University Thomayer Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,27]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Toxbase.Osmium. (2018).https:\/\/www.toxbase.org. Accessed April 1 2020."},{"key":"e_1_2_8_3_1","unstructured":"JoDrugs.Osmium tetroxide(2020).http:\/\/www.jodrugs.com\/toxicologies\/3241\u2010osmium\u2010tetroxide.aspx. Accessed April 1 2020."},{"key":"e_1_2_8_4_1","unstructured":"Micromedex.Osmium Tetroxide(2019).https:\/\/www.micromedexsolutions.com. Accessed April 1 2020."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.55B4.814"},{"key":"e_1_2_8_6_1","first-page":"750","article-title":"Osmium tetroxide: a new kind of weapon","volume":"9","author":"Makarovsky I","year":"2007","journal-title":"Isr Med Assoc J."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117392"},{"issue":"2","key":"e_1_2_8_8_1","first-page":"108","article-title":"Soluble transferrin receptor\u2010ferritin index in the evaluation of anemia in inflammatory bowel disease: a case\u2010control study","volume":"24","author":"Oustamanolakis P","year":"2011","journal-title":"Ann Gastroenterol."},{"issue":"2","key":"e_1_2_8_9_1","first-page":"87","article-title":"Membranous glomerulonephritis in rheumatoid arthritis not related to gold or D\u2010penicillamine therapy: a report of four cases and review of the literature","volume":"27","author":"Honkanen E","year":"1987","journal-title":"Clin Nephrol."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1201\/b13467"},{"key":"e_1_2_8_11_1","unstructured":"BartonJC EdwardsCQ.HFE Hemochromatosis. 2000 Apr 3 [Updated 2018 Dec 6]. In:AdamMP ArdingerHH PagonRA et al. eds.GeneReviews\u00ae [Internet].Seattle WA:University of Washington Seattle;1993\u20102020."}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcpt.13450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.13450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcpt.13450","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.13450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T19:56:29Z","timestamp":1693857389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.13450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,27]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/bcpt.13450"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.13450","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,27]]},"assertion":[{"value":"2020-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}