{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:28:01Z","timestamp":1778801281191,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Piper laetispicum<\/jats:italic> C. DC is one of the Chinese herbal medicines used for alleviating depressive disorders. G11\u20105 [3\u2010(3, 4\u2010methylenedioxy\u20105\u2010trifluoromethyl phenyl)\u20102<jats:italic>E<\/jats:italic>\u2010propenoic acid isobutyl amide] is synthesized based on the chemical structure of an active\u00a0integrant of <jats:italic>Piper laetispicum<\/jats:italic> C. DC. The present study assessed the antidepressant effect of G11\u20105 and investigated the underlying mechanism with learned helplessness (LH) and social defeat stress (SDS) mice model of depression. In the LH model, mice were exposed to 60 inescapable electric shocks once a day for three consecutive days followed by 2\u2010week drug administration and helpless behaviour assessment. In the SDS model, mice were subjected to repeated social defeat by an aggressive CD\u20101 mouse once a day for consecutive 10\u00a0days. Following oral administration for 2\u00a0weeks, the mice were subjected to a series of behavioural tests including social interaction test. G11\u20105 significantly decreased the number of escape failures induced by LH paradigm, meanwhile increased the social interaction ratio and shortened the immobility time in forced swimming test for the SDS\u2010exposed mice, suggesting remarkable antidepressant effect. Moreover, G11\u20105 ameliorated the changes in mitophagy\u2010related proteins induced by two stress exposures and restored retrograde axonal transport and neurotransmitter release. Our findings suggested that G11\u20105 exhibited an obvious antidepressant through TSPO\u2010mediated mitophagy pathway.<\/jats:p>","DOI":"10.1111\/bcpt.13452","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T17:37:49Z","timestamp":1591637869000},"page":"380-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antidepressant effects of 3\u2010(3,4\u2010methylenedioxy\u20105\u2010trifluoromethyl phenyl)\u20102E\u2010propenoic acid isobutyl amide involve TSPO\u2010mediated mitophagy signalling pathway"],"prefix":"10.1111","volume":"127","author":[{"given":"Qiang","family":"Wei","sequence":"first","affiliation":[{"name":"Medical College Tibet University Lhasa China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Research Centre Tasly Institute Tasly Holding Group Co., Ltd. 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