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Our aim was to investigate whether angiotensin\u2010converting enzyme inhibitor (ACEI) and angiotensin II type 1 receptor blocker (ARB) could inhibit scar formation in humans. Thus, an observational and hypothesis\u2010generating study using a designed questionnaire was carried out. A total of 347 patients with postoperative scars secondary to thyroid tumours were enrolled. They were divided into four groups: ACEI group, ARB group, other antihypertensive drugs control group and blank control group according to the administration of antihypertensive drugs. The width of scar was measured, and the Scar Cosmesis Assessment and Rating (SCAR) Scale was filled out. Results showed that patients of ACEI group (mean scar width 1.60\u00a0mm) and ARB group (mean scar width 1.57\u00a0mm) formed smaller scars than those of other antihypertensive drugs control group (mean scar width 2.09\u00a0mm) and blank control group (mean scar width 2.0\u00a0mm). Oral administration of ACEI and ARB may be associated with better post\u2010surgical scar formation in humans. These two kinds of antihypertensive drugs may be active components of anti\u2010scar medicine.<\/jats:p>","DOI":"10.1111\/bcpt.13458","type":"journal-article","created":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T18:49:37Z","timestamp":1592765377000},"page":"488-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Angiotensin\u2010converting enzyme inhibitor and angiotensin II type 1 receptor blocker: Potential agents to reduce post\u2010surgical scar formation in humans"],"prefix":"10.1111","volume":"127","author":[{"given":"Yan\u2010Yan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Qing","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding\u2010Ding","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4951-0960","authenticated-orcid":false,"given":"Wei\u2010Qiang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.06.091"},{"key":"e_1_2_7_3_1","first-page":"11","article-title":"Molecular and cellular mechanisms of angiotensin II\u2010mediated cardiovascular and renal diseases","volume":"52","author":"Kim S","year":"2000","journal-title":"Pharmacol Rev"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.0139.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.09.027"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14489"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21600-w"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2014.10.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-018-0066-x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.3757"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13059"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3401642"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2018.19.1.35"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182a8070c"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666161025144434"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002660010038"},{"key":"e_1_2_7_17_1","first-page":"197","article-title":"Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I\u2010converting enzyme (ACE) gene controls plasma ACE levels","volume":"51","author":"Tiret L","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy0202.103821"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.05.081"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6670"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1586\/eem.11.9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.14"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.a2017.0107"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701575RRR"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109394"}],"container-title":["Basic &amp; 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