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Resveratrol was administered orally during a period of 23\u00a0days. A major concern of the present work was to explore an ample range of daily doses (10\u2010200\u00a0mg\/kg). Several oxidative and inflammatory markers were measured. Important effects of resveratrol treatment were the normalization of the plasma myeloperoxidase activity (inflammatory marker), the normalization of the brain xanthine oxidase activity (reactive oxygen species source) and the near\u2010normalization of the catalase activity in the brain (antioxidant defence). These effects presented obvious dose dependencies in the range up to 200\u00a0mg\/kg. Resveratrol also reduced protein and lipid damage within the lowest dose ranges investigated, and its action as a free radical scavenger activity was enhanced in brain mitochondria of arthritic rats. Resveratrol failed in restoring the diminished albumin levels and plasma protein thiols in arthritic rats. The latter, however, were substantially increased in healthy rats at low doses (up to 50\u00a0mg\/kg), a sign of antioxidant action. This increase was reversed at higher doses, a sign of pro\u2010oxidant action. The observations agree with the notion that low doses of resveratrol might be useful as an adjuvant to the conventional antirheumatic drugs.<\/jats:p>","DOI":"10.1111\/bcpt.13475","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T20:25:36Z","timestamp":1597004736000},"page":"80-90","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Actions of multiple doses of resveratrol on oxidative and inflammatory markers in plasma and brain of healthy and arthritic rats"],"prefix":"10.1111","volume":"128","author":[{"given":"Lorena dos Santos","family":"Castro","sequence":"first","affiliation":[{"name":"Department of Biochemistry University of Maring\u00e1 Maring\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia","family":"Bracht","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Maring\u00e1 Maring\u00e1 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