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We systematically searched for studies of acute toxicity of quetiapine or other antipsychotics combined with morphine or methadone. Case reports describing toxicity of quetiapine combined with morphine or methadone were also included. We retrieved one human study that observed pharmacokinetic interaction between quetiapine and methadone, and 16 other human studies. Fourteen investigated the combination of droperidol and morphine in treatment doses, and some indicated an additive sedative effect. Five animal studies with acepromazine in combination with morphine or methadone were located and indicated an additive effect on sedation and hypotension. Six forensic case reports in which death could have been caused solely by quetiapine, the opioid, or other drugs were found. Thus, acute toxicity of quetiapine combined with morphine or methadone has not been studied. Because of quetiapine's effects on alpha\u2010adrenoceptors, muscarinic and histamine receptors, human ether\u2010a\u2010go\u2010go\u2010channels and methadone kinetics, we suggest further research to clarify if the indicated additive effects of opioids and droperidol or acepromazine are also true for quetiapine.<\/jats:p>","DOI":"10.1111\/bcpt.13480","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T14:59:06Z","timestamp":1597503546000},"page":"66-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Quetiapine and other antipsychotics combined with opioids in legal autopsy cases: A random finding or cause of fatal outcome?"],"prefix":"10.1111","volume":"128","author":[{"given":"Freja Drost","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-7666","authenticated-orcid":false,"given":"Ulf","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0543-6519","authenticated-orcid":false,"given":"Charlotte Uggerh\u00f8j","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus University Aarhus Denmark"},{"name":"Department of Clinical Pharmacology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494814525006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000738"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2015.01.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2004.05.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2017.12.020"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830130077015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2016.1164861"},{"issue":"3","key":"e_1_2_7_9_1","first-page":"A5207","article-title":"Psychiatric disorders are overlooked in patients with drug abuse","volume":"63","author":"Kruckow L","year":"2016","journal-title":"Dan Med J."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178221819844205"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000814"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2019.1671943"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.12.027"},{"key":"e_1_2_7_14_1","article-title":"Quetiapine is not a sleeping pill","author":"Debernard KAB","year":"2019","journal-title":"Tidsskrift for Den norske legeforening"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2012.03.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001053"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.3421"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2008.03.016"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.3793"},{"key":"e_1_2_7_20_1","unstructured":"FDA USFaDA.Full prescribing information seroquel XRwww.accesdata.fda.gov: U.S. Food and Drug Administration FDA;2013[Cited 2019\u201010\u201013]. 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