{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:01:48Z","timestamp":1781766108363,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gentamicin (GM) is an aminoglycoside antibiotic that despite its antibacterial effects, its use is restricted due to numerous side effects. The umbilical cord serum contains various biomolecules that have protective impacts on the damaged tissues. The aim of this study was to gauge the protective effect of human umbilical cord blood serum (hUCBS) on GM\u2010induced hepatotoxicity. In this experimental study, 28 male Wistar rats, weighing 220\u00a0\u00b1\u00a020\u00a0g, were randomly categorized into 4 groups including control, GM (100\u00a0mg\/kg), hUCBS at doses of 1 and 2% along with GM (100\u00a0mg\/kg) for 10\u00a0days, intraperitoneally. Twenty\u2010four hours after the last injection, direct blood sampling was taken from the heart to obtain blood serum and liver enzymes, inflammatory cytokines and liver tissue were examined for histology. GM causes necrosis and inflammation in liver tissue. Liver enzyme and inflammatory cytokine levels were significantly increased in the GM group. Human umbilical cord blood serum significantly decreased liver enzyme and inflammatory cytokines levels in the experimental groups compared to the GM group. GM causes liver damage such as the inflammation and necrosis in liver tissue. Treating the animals with hUCBS reduced the toxic effects of GM in the liver.<\/jats:p>","DOI":"10.1111\/bcpt.13502","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T06:18:28Z","timestamp":1601360308000},"page":"268-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Human umbilical cord blood serum attenuates gentamicin\u2010induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-3220","authenticated-orcid":false,"given":"Naser","family":"Mirazi","sequence":"first","affiliation":[{"name":"Department of Biology Faculty of Basic Sciences Bu\u2010Ali Sina University Hamedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Baharvand","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Basic Sciences Bu\u2010Ali Sina University Hamedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Moghadasali","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Developmental Biology Cell Sciences Research Center Royan Institute for Stem Cell Biology and Technology ACECR Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Nourian","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Faculty of Veterinary Science Bu\u2010Ali Sina University Hamedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolkarim","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Biotechnology Faculty of Life Sciences and Biotechnology Shahid Beheshti University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13439"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2010.06.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4037\/aacnacc2016324"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.527937"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000029"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0879-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.03.044"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031254"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2011.0488"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-010-9168-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12998"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13059"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(13)60098-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203936"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.01.088"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2019.1633354"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.100"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043384664"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.6.1889"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00407"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2019.108863"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.22462\/04.06.2019.5"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-9572(08)60017-0"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2019.1649218"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.02.049"}],"container-title":["Basic &amp; 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