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Inflammasome is one of the most important components of innate immunity, which exacerbates inflammation by increasing IL\u20101\u03b2 and IL\u201018 production. Studies on viral infections have shown overactivity of inflammasome and thus the occurrence of destructive and systemic inflammation in patients. NLRP3 inflammasome has been shown to play a key role in the pathogenesis of viral diseases. The proliferation of SARS\u2010CoV\u20102 in a wide range of cells can be combined with numerous observations of direct and indirect activation of inflammasome by other coronaviruses. Activation of the inflammasome is likely to be involved in the formation of cytokine storm. Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF\u2010kBERK1,2, AP\u20101, TGF\u2010\u03b2, TXNIP, STAT3, PPAR\u03b3, JAK2\u2010STAT3, NLRP3, p38MAPK, Nrf2, Notch\u20101, AMPK, TLR\u20104 and MyD\u201088. Due to anti\u2010inflammatory and anti\u2010inflammasome properties without any special side effects, curcumin can potentially play a role in the treatment of COVID\u201019 infection along with other drug regimens.<\/jats:p>","DOI":"10.1111\/bcpt.13503","type":"journal-article","created":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T01:53:21Z","timestamp":1603590801000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["COVID\u201019: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin?"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-1412","authenticated-orcid":false,"given":"Ali","family":"Saeedi\u2010Boroujeni","sequence":"first","affiliation":[{"name":"Department of Immunology Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Abadan School of Medical Sciences Abadan Iran"},{"name":"ImmunologyToday Universal Scientific Education and Research Network (USERN) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1096-5661","authenticated-orcid":false,"given":"Mohammad\u2010Reza","family":"Mahmoudian\u2010Sani","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-9799","authenticated-orcid":false,"given":"Mohammad","family":"Bahadoram","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3482-2195","authenticated-orcid":false,"given":"Arash","family":"Alghasi","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108427"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0311-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-2004-168"},{"key":"e_1_2_7_5_1","article-title":"The landscape of lung bronchoalveolar immune cells in COVID\u201019 revealed by single\u2010cell RNA sequencing","author":"Liao M","year":"2020","journal-title":"medRxiv."},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"A review on pharmacological effects and therapeutic properties of curcumin","volume":"2","author":"Modaresi M","year":"2017","journal-title":"J Med Plants."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46401-5"},{"key":"e_1_2_7_8_1","first-page":"44","article-title":"Turmeric and curcumin: biological actions and medicinal applications","volume":"87","author":"Chattopadhyay I","year":"2004","journal-title":"Curr Sci."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm800683f"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-0-387-46401-5_11","volume-title":"Cell growth regulation. 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