{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:43:58Z","timestamp":1747183438317,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nifekalant has been used in the treatment of atrial arrhythmia recently. However, there is no consensus on the preferable nifekalant dose to treat atrial fibrillation (AF). The purpose of this study was to explore efficacy and safety of different doses of nifekalant in the cardioversion of persistent AF. The study was a single\u2010centre, randomized controlled trial. All subjects received nifekalant or placebo intravenously, and the nifekalant was given at the dosage of 0.3, 0.4 or 0.5\u00a0mg\/kg. Primary efficacy end\u2010point: compared with 0.3\u00a0mg group, the rate of cardioversion to sinus rhythm from AF in 0.4 and 0.5\u00a0mg group was higher. The 0.4 and 0.5\u00a0mg\/kg doses were associated with a similar magnitude of efficacy (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). Secondary efficacy end\u2010point: termination rates of AF in the group of 0.4\u00a0mg and 0.5\u00a0mg were higher than 0.3\u00a0mg. Primary safety end\u2010point: the rate of Torsades de Pointes or ventricular fibrillation was numerically lower in the 0.4\u00a0mg group than 0.5\u00a0mg group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). Secondary safety end\u2010point: The rates of the majority of other common drug\u2010related adverse events in the group of 0.5 and 0.4\u00a0mg were higher than the 0.3\u00a0mg group. A 0.4\u00a0mg\/kg dose of intravenous nifekalant may be recommended during the radiofrequency ablation for persistent AF considering the benefit\u2010risk profile.<\/jats:p>","DOI":"10.1111\/bcpt.13513","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T05:39:11Z","timestamp":1602308351000},"page":"430-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the efficacy and safety of different doses of nifekalant in the instant cardioversion of persistent atrial fibrillation during radiofrequency ablation"],"prefix":"10.1111","volume":"128","author":[{"given":"Zhenyu","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang 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