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Tissues were isolated from male BALB\/c mice and incubated with LPS (10\u00a0\u00b5g\/mL) in tissue culture. The subgroups were incubated with NaHS, GYY4137 and mitochondria\u2010targeted donor AP39. LPS incubation did not alter contraction response to carbachol, but enhanced 5\u2010HT and bradykinin\u2010induced contractions in tracheal rings, and elevated IL\u20101\u03b2, IL\u20106 and TNF\u2010\u03b1 levels in lung homogenates. NaHS at 300\u00a0\u00b5mol\/L and 1000\u00a0\u00b5mol\/L, GYY4137 at 30\u00a0\u00b5mol\/L and 100\u00a0\u00b5mol\/L, and AP39 at 30\u00a0nmol\/L concentrations inhibited the tracheal hyperreactivity to 5\u2010HT, whereas none of these donors affected the enhanced contraction to bradykinin. GYY4137 was also effective to inhibit 5\u2010HT hyperreactivity acutely. In lung tissues, NaHS prevented the elevation of IL\u20101\u03b2 level at 1000\u00a0\u03bcmol\/L, and IL\u20106 and TNF\u2010\u03b1 levels at 100\u00a0\u03bcmol\/L concentrations. Incubation with GYY4137 (100\u00a0\u00b5mol\/L) and AP39 (30\u00a0nmol\/L and 300\u00a0nmol\/L) inhibited the increase in IL\u20106 and TNF\u2010\u03b1 levels, but not IL\u20101\u03b2 at concentrations that they affected tracheal hyperreactivity. These results indicate that H<jats:sub>2<\/jats:sub>S donors can decrease inflammation and prevent airway hyperreactivity.<\/jats:p>","DOI":"10.1111\/bcpt.13551","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T18:08:31Z","timestamp":1608833311000},"page":"652-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hydrogen sulfide donors prevent lipopolysaccharide\u2010induced airway hyperreactivity in an in vitro model of chronic inflammation in mice"],"prefix":"10.1111","volume":"128","author":[{"given":"Yasemin","family":"Karaman","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmacology Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim","family":"Kaya\u2010Yasar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmacology Karadeniz Technical University Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8650-176X","authenticated-orcid":false,"given":"T Emrah","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmacology Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inci","family":"Sahin\u2010Erdemli","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmacology Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.3_suppl.411S"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00714.2012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20234"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.12.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.11.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6255com"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0114TR"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.11.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2012.03.009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.904"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2017.06.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.SC0070199"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2899"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3583fje"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.04.014"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001210"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.04.008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704928"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13059"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33101-x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0415OC"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702304"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.173054"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0262"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03756.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-8-29"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.07.026"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.03.020"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00414.2011"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00320.2015"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.257790"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-04-0250"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.02.033"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0369OC"}],"container-title":["Basic &amp; 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