{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:05Z","timestamp":1787013905612,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760079"],"award-info":[{"award-number":["81760079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The main causes of lung injury after cardiopulmonary bypass (CPB) are systemic inflammatory response syndrome (SIRS) and pulmonary ischaemia\u2010reperfusion injury (IR\u2010I). SIRS and IR\u2010I are often initiated by a systemic inflammatory response. The present study investigated whether the annexin A1 (ANX\u2010A1) peptidomimetic Ac2\u201026 by binding to formyl peptide receptors (FPRs) inhibit inflammatory cytokines and reduce lung injury after CPB. Male rats were randomized to the following five groups (n\u00a0=\u00a06, each): sham, exposed to pulmonary ischaemic\u2010reperfusion (IR\u2010I), IR\u2010I plus Ac2\u201026, IR\u2010I plus the FPR antagonist, BoC2 (N\u2010tert\u2010butyloxycarbonyl\u2010Phe\u2010Leu\u2010Phe\u2010Leu\u2010Phe) and IR\u2010I plus Ac2\u201026 and BoC2. Treatment with Ac2\u201026 improved the oxygenation index, an effect blocked by BoC2. Histopathological analysis of the lung tissue revealed that the degree of lung injury was significantly less (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) in the Ac2\u201026\u2010treated rats compared to the other experimental groups exposed to IR\u2010I. Ac2\u201026 treatment reduced the levels of the inflammatory cytokines TNF\u2010\u03b1, IL\u20101\u03b2, ICAM\u20101 and NF\u2010\u03baB\u2010p65 (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) compared to the vehicle\u2010treated group exposed to IR\u2010I. In conclusion, the annexin A1 (ANX\u2010A1) peptidomimetic Ac2\u201026 by binding to formyl peptide receptors inhibit inflammatory cytokines and reduce ischaemic\u2010reperfusion lung injury after cardiopulmonary bypass.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.13561","type":"journal-article","created":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T06:00:41Z","timestamp":1610863241000},"page":"719-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The role and mechanism of the annexin A1 peptide Ac2\u201026 in rats with cardiopulmonary bypass lung injury"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1781-5295","authenticated-orcid":false,"given":"Jiyang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Zunyi Medical University Zunyi China"},{"name":"Guizhou Key Laboratory of Anesthesia and Organ Protection Zunyi Medical University Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengkun","family":"Yu","sequence":"additional","affiliation":[{"name":"Guizhou Key Laboratory of Anesthesia and Organ Protection Zunyi Medical University Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Zunyi Medical University Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Zunyi Medical University Zunyi China"},{"name":"Guizhou Key Laboratory of Anesthesia and Organ Protection Zunyi Medical University Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Guizhou Key Laboratory of Anesthesia and Organ Protection Zunyi Medical University Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8871-0124","authenticated-orcid":false,"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Zunyi Medical University Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"54","article-title":"Epidural analgesia for adults undergoing cardiacsurgery with or without cardiopulmonary bypass","volume":"1","author":"Guay J","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39742-w"},{"key":"e_1_2_9_4_1","first-page":"A5790","article-title":"Ischemic lung injury following cardio\u2010pulmonary bypass (cpb) is associated with inflammation and differentiation. 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