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Oral glucose tolerance test was performed to evaluate glucose metabolism. Moreover, blood and hepatic biochemical and histological indices were detected. Besides, Affymetrix\u2010GeneChip analysis and Western blot of the liver were performed. Comparing to the monotherapy group, BFOV\u00a0+\u00a0Met showed more effective improvement in glucose metabolism, which decreased the fasting blood glucose, insulin levels and improved insulin sensitivity in HFC57 mice. BFOV\u00a0+\u00a0Met significantly decreased serum ALT and AST activities and reduced hepatic triglyceride content and iNOS activities, accompanied by ameliorating intrahepatic fat accumulation and hepatocellular vacuolation. Enhanced hepatic insulin signalling transduction and attenuated inflammation pathway were identified as the major pathways in the BFOV\u00a0+\u00a0Met group. BFOV\u00a0+\u00a0Met significantly down\u2010regulated the protein expression levels of MMPs, NF\u2010\u03baB, iNOS and up\u2010regulated phosphorylation of AKT and AMPK levels. We concluded that a combination of BFOV and metformin ameliorates hepatic steatosis in HFC57 mice via alleviating hepatic inflammation and enhancing insulin signalling pathway, suggesting that the combination of BFOV and metformin is a potential treatment for hepatic steatosis.<\/jats:p>","DOI":"10.1111\/bcpt.13573","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T09:13:15Z","timestamp":1613639595000},"page":"747-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Combination of bis (\u03b1\u2010furancarboxylato) oxovanadium (IV) and metformin improves hepatic steatosis through down\u2010regulating inflammatory pathways in high\u2010fat diet\u2010induced obese C57BL\/6J mice"],"prefix":"10.1111","volume":"128","author":[{"given":"Quan","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Key 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