{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:43:00Z","timestamp":1783993380484,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007137","name":"Helse Nord RHF","doi-asserted-by":"publisher","award":["Project ID: SFP1248\u201015"],"award-info":[{"award-number":["Project ID: SFP1248\u201015"]}],"id":[{"id":"10.13039\/501100007137","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following intake of a single dose, each participant collected seven breast milk samples at predefined intervals up to 24\u00a0hours after dose. Triptan concentrations in milk were measured using liquid chromatography\u2010tandem mass spectrometry (LC\u2010MS\/MS). Infant drug exposure was estimated by calculating the relative infant dose (RID). Twenty\u2010two breast milk sample sets were obtained for sumatriptan (n\u00a0=\u00a08), rizatriptan (n\u00a0=\u00a05), zolmitriptan (n\u00a0=\u00a04), eletriptan (n\u00a0=\u00a03), almotriptan (n\u00a0=\u00a01) and naratriptan (n\u00a0=\u00a01). Based on the average concentration in milk throughout the day, estimated mean RIDs (with range in parenthesis) were as follows: eletriptan 0.6% (0.3%\u20100.8%), sumatriptan 0.7% (0.2%\u20101.8%), rizatriptan 0.9% (0.3%\u20101.4%), almotriptan 1.8% (\u2010), zolmitriptan 2.1% (0.7%\u20105.3%) and naratriptan 5.0% (\u2010). Infant drug exposure through breastfeeding appears to be low and indicates that use of the triptans in this study is compatible with breastfeeding. Naratriptan may not be first choice in breastfeeding mothers initiating triptans during the neonatal period.<\/jats:p>","DOI":"10.1111\/bcpt.13579","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T19:41:21Z","timestamp":1616010081000},"page":"795-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2786-9852","authenticated-orcid":false,"given":"Siri","family":"Amundsen","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine University Hospital of North Norway Troms\u00f8 Norway"},{"name":"Experimental and Clinical Pharmacology Research Group Department of Medical Biology Faculty of Health Sciences UiT \u2013 The Arctic University of Norway Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6361-2918","authenticated-orcid":false,"given":"Hedvig","family":"Nordeng","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology and Drug Safety Research Group Department of Pharmacy University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4733-0499","authenticated-orcid":false,"given":"Ole\u2010Martin","family":"Fuskev\u00e5g","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University Hospital of North Norway Troms\u00f8 Norway"},{"name":"Experimental and Clinical Pharmacology Research Group Department of Medical Biology Faculty of Health Sciences UiT \u2013 The Arctic University of Norway Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Nordmo","sequence":"additional","affiliation":[{"name":"Regional Medicines Information and Pharmacovigilance Centre (RELIS) University Hospital of North Norway Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-5881","authenticated-orcid":false,"given":"Georg","family":"Sager","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Pharmacology Research Group Department of Medical Biology Faculty of Health Sciences UiT \u2013 The Arctic University of Norway Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-9014","authenticated-orcid":false,"given":"Olav","family":"Spigset","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology St. Olav University Hospital Trondheim Norway"},{"name":"Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12601"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/11537990-000000000-00000"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.8542"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00480.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0329-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1996.tb00185.x"},{"key":"e_1_2_7_8_1","volume-title":"Hale's Medications & Mothers' Milk: A Manual of Lactational Pharmacology","author":"Hale TW","year":"2021"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13492"},{"key":"e_1_2_7_10_1","unstructured":"U.S. Food and Drug Administration (FDA).Clinical lactation studies: considerations for study design 2019.https:\/\/www.fda.gov\/media\/124749\/download. 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