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In this study, we primarily researched parts of the pharmacological and toxicological properties of an analgesic conotoxin lt14a. Three doses of lt14a (1, 5 and 10\u00a0mg\/kg) could prolong the pentobarbital\u2010induced sleep time of mice and showed no significant effect on the spontaneous locomotor activity of mice. Three doses of lt14a (50, 100 and 200\u00a0mg\/kg) did not increase micronucleus rate in the micronucleus test. In addition, three doses of lt14a (200, 500 and 1000\u00a0mg\/kg) showed no pathological change on the heart or brain of mice in the acute toxicity test. The high dose of lt14a (1000 times the effective analgesic dose) had a certain damaging effect on the liver and lung according to serological detection and histopathology. As part of the preclinical studies, our results provide acute toxicity and mutagenicity evaluation of the promising analgesic conotoxin lt14a.<\/jats:p>","DOI":"10.1111\/bcpt.13582","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T01:36:44Z","timestamp":1616204204000},"page":"52-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute toxicity and micronucleus test of conotoxin lt14a in mice"],"prefix":"10.1111","volume":"129","author":[{"given":"Yun","family":"Wu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics Guangdong Medical University Dongguan China"},{"name":"National Engineering Research Center of South China Sea Marine Biotechnology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Qiang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of South China Sea Marine Biotechnology Guangzhou China"},{"name":"Ningxia Key Laboratory for Cerebrocranical Disease Ningxia Medical University Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxian","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of South China Sea Marine Biotechnology Guangzhou China"},{"name":"China School of Fundamental Medical Sciences Guangzhou University of Chinese Medicine Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0603-5223","authenticated-orcid":false,"given":"Maojun","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of South China Sea Marine Biotechnology Guangzhou China"},{"name":"Department of Oncology NHC Key Laboratory of Cancer Proteomics Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00207"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082495"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MB00511C"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr886"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2014.03.018"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030788"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2006.06.014"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.04.016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2010.11.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2015.01.013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199412000123"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13059"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2014.08.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-016-1025-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2011.561438"},{"key":"e_1_2_8_17_1","first-page":"296","article-title":"Fast onset of action and the analgesic and sedative efficacy of essential oil from Rhizoma Chuanxiong after nasal administration","volume":"65","author":"Guo J","year":"2010","journal-title":"Pharmazie"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-007-0177-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2018.12.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480380"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501334112"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.12.050"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2020.170468"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/gew013"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1091581820977846"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2018.09.004"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0107-5"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.08.047"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.06.023"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.04.022"}],"container-title":["Basic &amp; 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