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At least 300 clinical trials are underway for drug repurposing against COVID\u201019; the clinician needs objective evidence\u2010based medication to treat COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Observations<\/jats:title><jats:p>Single\u2010stranded RNA viral genome of SARS\u2010CoV\u20102 encodes structural proteins (spike protein), non\u2010structural enzymatic proteins (RNA\u2010dependent RNA polymerase, helicase, papain\u2010like protease, 3\u2010chymotrypsin\u2010like protease) and other accessory proteins. These four enzymatic proteins on spike protein are rate\u2010limiting steps in viral replications and, therefore, an attractive target for drug development against SARS\u2010CoV\u20102. In silico and in vitro studies have identified various potential epitomes as candidate sequences for vaccine development. These studies have also revealed potential targets for drug development and drug repurposing against COVID\u201019. Clinical trials utilizing antiviral drugs and other drugs have given inconclusive results regarding their clinical efficacy and side effects. The need for angiotensin\u2010converting enzyme (ACE\u20102) inhibitors\/angiotensin receptor blockers and corticosteroids has been recommended. Western countries have adopted telemedicine as an alternative to prevent transmission of infection in the population. Currently, no proven, evidence\u2010based therapeutic regimen exists for COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The COVID\u201019 pandemic has put tremendous pressure on researchers to evaluate and approve drugs effective against the disease. 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