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The current treatment options of IBD are not curative and are lacking in aspects like prevention of fibrosis. New treatment options are needed to fulfil the unmet needs and provide alternatives to drugs with resistances and side effects. Drugs targeting the renin\u2013angiotensin system (RAS), besides being antihypertensive, also possess anti\u2010inflammatory and antifibrotic properties and could offer an inexpensive alternative to control inflammation and fibrosis in the gut. RAS inhibitors have been effective in preventing and alleviating colitis in preclinical studies, but available human data are still sparse. This review outlines the pathophysiological functions of RAS in the gut and summarizes preclinical studies utilizing pharmacological RAS inhibitors in the treatment of experimental colitis. We discuss the alterations in intestinal RAS and the available evidence of the benefits of RAS inhibitors for IBD patients. Retrospective studies comparing IBD patients using ACE inhibitors or angiotensin II receptor blockers have provided optimistic results regarding a milder disease course and fewer hospitalizations and corticosteroid use in patients using RAS inhibitors. Prospective studies are needed to evaluate the effectiveness of these promising medications in the treatment of IBD.<\/jats:p>","DOI":"10.1111\/bcpt.13624","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T07:38:59Z","timestamp":1623742739000},"page":"161-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Renin\u2013angiotensin system in intestinal inflammation\u2014Angiotensin inhibitors to treat inflammatory bowel diseases?"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3418-152X","authenticated-orcid":false,"given":"Hanne","family":"Salmenkari","sequence":"first","affiliation":[{"name":"Folkh\u00e4lsan Institute of Genetics Folkh\u00e4lsan Research Center  Helsinki Finland"},{"name":"Research Program for Clinical and Molecular Metabolism, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Department of Nephrology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-9186","authenticated-orcid":false,"given":"Riitta","family":"Korpela","sequence":"additional","affiliation":[{"name":"Pharmacology, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Research Program for Human Microbiome, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4348-8555","authenticated-orcid":false,"given":"Heikki","family":"Vapaatalo","sequence":"additional","affiliation":[{"name":"Pharmacology, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02165.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071098"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.05.029"},{"key":"e_1_2_9_6_1","unstructured":"SalmenkariH.Renin\u2010Angiotensin System in Intestinal Inflammation\u2014Experimental Studies with Therapeutic Interventions. 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