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This study aimed to characterise the pharmacokinetic\u2010pharmacodynamic relationships of oxycodone from a lipid\u2010based and water\u2010swellable controlled\u2010release tablet in RYGB patients. Twenty RYGB patients received 10\u2010mg oral solution oxycodone or 20\u2010mg controlled\u2010release (water\u2010swellable or lipid\u2010based) oxycodone in a three\u2010way, randomised, semiblinded and cross\u2010over study. Blood sampling and pupillary recordings were conducted over a 24\u2010h period. A previously established pharmacokinetic\u2010pharmacodynamic model of these three formulations in healthy volunteers was used in the analysis as a reference model. No differences in absorption kinetics were seen between controlled\u2010release formulations in patients. However, the absorption lag time was 11.5\u2009min in patients vs 14\u2009min in healthy volunteers for controlled\u2010release tablets (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Furthermore, oral bioavailability was 14.4% higher in patients compared to healthy volunteers regardless of formulation type (<jats:italic>P\u2009&lt;<\/jats:italic>\u00a00.001). Oxycodone pharmacodynamics were not significantly affected by formulation or patient status. However, baseline pupil diameter was inversely correlated with age (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and plasma concentrations of oxycodone at half\u2010maximum effect were 31% lower in males compared to females (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Generic substitution of monophasic lipid\u2010based and water\u2010swellable controlled\u2010release oxycodone tablets may be considered safe in RYGB patients.<\/jats:p>","DOI":"10.1111\/bcpt.13634","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T16:55:20Z","timestamp":1625590520000},"page":"232-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Roux\u2010en\u2010Y gastric bypass on the pharmacokinetic\u2010pharmacodynamic relationships of liquid and controlled\u2010release formulations of oxycodone"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5849-5358","authenticated-orcid":false,"given":"Louise","family":"Ladebo","sequence":"first","affiliation":[{"name":"Mech\u2010Sense, Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-065X","authenticated-orcid":false,"given":"Ahmad Y.","family":"Abuhelwa","sequence":"additional","affiliation":[{"name":"Australian Centre for Precision Health, Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"},{"name":"Discipline of Clinical Pharmacology, College of Medicine and Public Health Flinders University  Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7345-4084","authenticated-orcid":false,"given":"David J. 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