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Retinoid orphan receptor gamma t (ROR\u03b3t) is a therapeutic target for several diseases; however, it is unclear whether inhibiting ROR\u03b3t can ameliorate AP. The relative expression of ROR\u03b3t, IL\u201017 and IL\u201023 in the peripheral blood mononuclear cells of AP patients was measured by RT\u2010PCR. An AP mouse model was induced by ceruletide, and SR1001 was injected before ceruletide administration. ROR\u03b3t+ cells, T helper 17 cells (Th17), regulatory T cells (Tregs) and \u03b3\u03b4 T cells were assessed in the pancreas and spleen by flow cytometry. Higher ROR\u03b3t expression in patients indicated the potential role of ROR\u03b3t in AP progression. Analyses of the IL\u201017\/IL\u201023 axis confirmed its role. SR1001 significantly alleviated AP histologically in the mouse model. Serum levels of amylase, IL\u20106, TNFalpha, IL\u201017 and IL\u201023 decreased upon SR1001 treatment. SR1001 selectively decreased the number of ROR\u03b3t+, Th17, Tregs and \u03b3\u03b4 T cells in the pancreas but not the spleen. Collectively, these results showed that SR1001 exerted therapeutic effects on AP by suppressing IL\u201017\u2010secreting Th17 and \u03b3\u03b4 T cells in the pancreas. Thus, SR1001 may be a promising drug for the treatment of AP in the clinic.<\/jats:p>","DOI":"10.1111\/bcpt.13642","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T21:59:22Z","timestamp":1628805562000},"page":"357-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["ROR\u03b3t inhibitor SR1001 alleviates acute pancreatitis by suppressing pancreatic IL\u201017\u2010producing Th17 and \u03b3\u03b4\u2010T cells in mice with ceruletide\u2010induced pancreatitis"],"prefix":"10.1111","volume":"129","author":[{"given":"Jianfa","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery, Minhang Hospital Fudan University  Shanghai China"},{"name":"Institute of Fudan\u2010Minhang Academic Health System, Minhang Hospital Fudan University  Shanghai 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Minhang Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xubo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery, Minhang Hospital Fudan University  Shanghai China"},{"name":"Institute of Fudan\u2010Minhang Academic Health System, Minhang Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-007X","authenticated-orcid":false,"given":"Ziping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery, Minhang Hospital Fudan University  Shanghai China"},{"name":"Institute of Fudan\u2010Minhang Academic Health System, Minhang Hospital Fudan University  Shanghai 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