{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:36:50Z","timestamp":1777617410415,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study examined the association between vancomycin (VCM) trough concentration and confounding factors including renal hypoperfusion medications which include angiotensin\u2010converting enzyme inhibitors\/angiotensin receptor blockers, loop\/thiazide diuretics, or non\u2010steroidal anti\u2010inflammatory drugs. This secondary analysis included patients aged &gt;15\u2009years who were administered VCM intravenously between June 2015 and August 2017 at the Tokyo Women's Medical University Medical Center East. We investigated predictors for three (initial, mean, and final) dose\u2010normalized VCM trough concentration (dose\u2010normalized VCM<jats:sub>trough<\/jats:sub>) as outcome using a multiple linear regression analysis. In total, 208 patients were analysed (use of loop\/thiazide diuretics: 48 [23%]). Multiple linear regression analysis revealed that the initial dose\u2010normalized VCM<jats:sub>trough<\/jats:sub> was negatively correlated with estimated glomerular filtration rate (eGFR) (<jats:italic>p<\/jats:italic>\u2009=\u20090.028) and positively correlated with the use of loop\/thiazide diuretics (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). Meanwhile, there was a positive correlation between the mean dose\u2010normalized VCM<jats:sub>trough<\/jats:sub> and age (<jats:italic>p<\/jats:italic>\u2009=\u20090.023). The mean dose\u2010normalized VCM<jats:sub>trough<\/jats:sub> was negatively correlated with eGFR (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and serum albumin (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The final dose\u2010normalized VCM<jats:sub>trough<\/jats:sub> was positively associated with age (<jats:italic>p<\/jats:italic>\u2009=\u20090.034) and negatively associated with eGFR (<jats:italic>p<\/jats:italic>\u2009=\u20090.032) and serum albumin (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). Clinicians should closely monitor VCM trough concentration while receiving VCM and loop\/thiazide diuretics.<\/jats:p>","DOI":"10.1111\/bcpt.13646","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T05:21:20Z","timestamp":1629091280000},"page":"376-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Involvement of the effect of renal hypoperfusion medications on vancomycin trough concentration: A secondary analysis using a retrospective observational data"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3898-2068","authenticated-orcid":false,"given":"Toshinori","family":"Hirai","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Mie University Hospital, Faculty of Medicine Mie University  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Hanada","sequence":"additional","affiliation":[{"name":"Department of Pharmacometrics and Pharmacokinetics Meiji Pharmaceutical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mie University Hospital, Faculty of Medicine Mie University  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimasa","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tokyo Women's Medical University Medical Center East  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq146"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2011.12.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080434"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077169"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa184"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199804000-00003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03679.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.4934-4941.2005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.19.2138"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-019-02648-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.132"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.67110.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90126-X"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13492"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfs013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01568-12"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S52259"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00303-16"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.917560"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra064398"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2010.68"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.04.018"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2008.01016.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir124"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12199"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00774.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325819850419"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.6.848"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199504000-00001"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2015.02.009"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155209355847"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-1928-z"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-2909-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2234"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.5114\/ait.2019.87362"}],"container-title":["Basic &amp; 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