{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:10:06Z","timestamp":1790172606432,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["7016\u201000052B"],"award-info":[{"award-number":["7016\u201000052B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the impact of genetic variants in <jats:italic>OCT1<\/jats:italic> (<jats:italic>SLC22A1<\/jats:italic>) on morphine, morphine\u20103\u2010glucuronide (M3G) and morphine\u20106\u2010glucuronide (M6G) pharmacokinetics in adult patients scheduled for major surgery. Blood samples were taken before and 5, 10, 15, 30, 45, 60 and 90\u2009min after a bolus of morphine (0.15\u2009mg\/kg). Patients were genotyped for the genetic variants (rs12208357, rs34059508, rs72552763 and rs34130495) in <jats:italic>OCT1<\/jats:italic>.<\/jats:p><jats:p>Eighty\u2010six patients completed the trial. The mean difference (95% confidence interval) for dose adjusted morphine, M3G and M6G AUC was 0.9 (\u22120.7\u20132.4), \u22125.9 (\u221211.8 to \u22120.03) and \u22121.1 (\u22122.5\u20130.4) h\/L*10<jats:sup>\u22126<\/jats:sup>, respectively, in patients with two reduced function alleles compared to patients with no reduced function alleles in <jats:italic>OCT1<\/jats:italic>. Accordingly, the (AUC<jats:sub>M3G\/Dose<\/jats:sub>)\/(AUC<jats:sub>morphine\/Dose<\/jats:sub>) and (AUC<jats:sub>M6G\/Dose<\/jats:sub>)\/(AUC<jats:sub>morphine\/Dose<\/jats:sub>) ratio was reduced, \u22121.8 (\u22123.2 to \u22120.4) and \u22120.4 (\u22120.7 to \u22120.03), respectively, when comparing the same groups. <jats:italic>OCT1<\/jats:italic> variants had no influence on the experience of pain, adverse events or the number of PCA doses used. In conclusion, genetic variants in <jats:italic>OCT1<\/jats:italic> had a small and clinically unimportant impact on the exposure of morphine after intravenous administration. Our results do not support pre\u2010emptive genotyping for <jats:italic>OCT1<\/jats:italic> prior to morphine administration in patients scheduled for major surgery.<\/jats:p>","DOI":"10.1111\/bcpt.13667","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T10:43:00Z","timestamp":1633344180000},"page":"93-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1727-1264","authenticated-orcid":false,"given":"Ida","family":"Kuhlmann","sequence":"first","affiliation":[{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Hjelmar 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