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Therefore, the aim of this study was to characterize the electrophysiological effects of certain NSAIDs in an established whole heart model of proarrhythmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Thirty\u2010eight hearts of New Zealand White rabbits were harvested and retrogradely perfused employing a Langendorff setup, and electrophysiology studies were performed to investigate action potential duration at 90% of repolarization (APD<jats:sub>90<\/jats:sub>), QT intervals, and effective refractory period (ERP). After generating baseline data, hearts were perfused with ibuprofen (Group 1, <jats:italic>n<\/jats:italic>\u00a0=\u200912; 10 and 30\u2009\u03bcM), indomethacin (Group 2, <jats:italic>n<\/jats:italic>\u00a0=\u200913; 10 and 20\u2009\u03bcM) and diclofenac (Group 3, <jats:italic>n<\/jats:italic>\u00a0=\u200913; 10 and 20\u2009\u03bcM), respectively, and the pacing protocols were repeated for each concentration. In all groups, perfusion with the NSAIDs resulted in a significant and reproducible shortening of APD<jats:sub>90<\/jats:sub> and QT interval. In all groups, the arrhythmia susceptibility was significantly raised as occurrence of monomorphic ventricular tachycardia under programmed ventricular stimulation was significantly increased under perfusion with ibuprofen, indomethacin and diclofenac in all concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The perfusion with ibuprofen, indomethacin and diclofenac in commonly used doses raised the arrhythmia susceptibility in an established rabbit whole\u2010heart model while APD shortening and shortened ERP seem to be crucial for arrhythmogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcpt.13671","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T17:28:38Z","timestamp":1633973318000},"page":"103-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Experimental evidence for proarrhythmic effects of nonsteroidal anti\u2010inflammatory drugs in a sensitive whole\u2010heart model"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9344-7826","authenticated-orcid":false,"given":"Julian","family":"Wolfes","sequence":"first","affiliation":[{"name":"Department of Cardiology II (Electrophysiology) University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ellermann","sequence":"additional","affiliation":[{"name":"Department of Cardiology II (Electrophysiology) University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"B\u00e4umer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Heimtiere, Reptilien und V\u00f6gel University of Veterinary Medicine Hannover, Foundation  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fehr","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Heimtiere, Reptilien und V\u00f6gel University of Veterinary Medicine Hannover, Foundation  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Willy","sequence":"additional","affiliation":[{"name":"Department of Cardiology II (Electrophysiology) University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Wegner","sequence":"additional","affiliation":[{"name":"Department of Cardiology II (Electrophysiology) University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick R.","family":"Leitz","sequence":"additional","affiliation":[{"name":"Department of Cardiology II (Electrophysiology) University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Eckardt","sequence":"additional","affiliation":[{"name":"Department of Cardiology II (Electrophysiology) University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Frommeyer","sequence":"additional","affiliation":[{"name":"Department of Cardiology II (Electrophysiology) University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530230056031"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050291"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c7086"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90006-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90461-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2008.00754.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(90)90151-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1988.tb11458.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053255"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199809000-00013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13492"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.288"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12769"},{"issue":"11","key":"e_1_2_7_15_1","first-page":"1211","article-title":"Biological availability of gastric juice\u2010resistant coated diclofenac preparations. 1. 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