{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:44:20Z","timestamp":1747183460608,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470864"],"award-info":[{"award-number":["81470864"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A fibrotic liver may have an impaired regenerative capacity. Because liver transplantation is donor limited, understanding the regenerative ability of a fibrotic liver is important.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A two\u2010thirds partial hepatectomy (PH) was performed in C57Bl\/6 mice with or without carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) treatment. Liver regeneration in the fibrotic liver after PH was assessed by the intrahepatic expression of the cell cycle regulators p53, p21, cyclin D1, c\u2010Fos and CDK2 using Western blot analysis. In addition, the expression of PGC\u20101\u03b1 and the cell proliferation\u2010related proteins PCNA and phosphate histone H3 was determined by Western blot and immunohistochemical staining analyses. Histone epigenetic modification of the PGC\u20101\u03b1 promoter was investigated through chromatin immunoprecipitation (ChIP) and reverse transcription\u2013quantitative polymerase chain reaction (RT\u2010qPCR) assays. The impact of PGC\u20101\u03b1 on liver regeneration after PH was further evaluated in PGC\u20101\u03b1\u2010knockout mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A decreased expression of PGC\u20101\u03b1 and liver regeneration\u2010related genes in the fibrotic liver was detected after a PH. Histone acetylation at the PGC\u20101\u03b1 promoter led to increases in PGC\u20101\u03b1 expression and the survival rate in the fibrotic group after a PH. PGC\u20101\u03b1\u2010mediated liver regeneration was further demonstrated in PGC\u20101\u03b1<jats:sup>f\/f<\/jats:sup>albcre<jats:sup>+\/0<\/jats:sup> mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Targeting PGC\u20101\u03b1 may represent a strategy to improve the treatment of PH in patients with liver fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcpt.13697","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T16:08:32Z","timestamp":1638288512000},"page":"254-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Peroxisome proliferator\u2010activated receptor gamma coactivator 1\u2010alpha protects a fibrotic liver from partial hepatectomy\u2010induced advanced liver injury through regulating cell cycle arrest"],"prefix":"10.1111","volume":"130","author":[{"given":"Linzhong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lipeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanghao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences Capital Medical University  Beijing 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