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ZJP could significantly inhibit VEN pharmacokinetics in vitro and in rats through suppression of CYP2D6 activity. To date, however, no clinical study has demonstrated the clinical relevance. Here, the VEN pharmacokinetics at a single dose of VEN with or without co\u2010administration of ZJP was compared. ZJP had a weak herb\u2013drug interactions (HDI) on the pharmacokinetics of VEN. The geometric means of<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>and AUC<jats:sub>0\u2010\u221e<\/jats:sub>of VEN increased by 36.7% and 34.6%, respectively, and the corresponding 90% confidence intervals (CIs) of geometric mean ratios (GMRs) exceed outside bioequivalent range of 0.80\u20131.25. However, the corresponding 90% CIs of GMRs of these parameters for ODV were within the range. Since ODV exposure (AUC), approximately 3.4\u2010fold higher than that of VEN, hardly changed, the systemic exposure of VEN active moiety (VEN\u2009+\u2009ODV) with ZJP increased slightly (\u22648.5%) compared with that of VEN alone. In addition, the incidence of VEN\u2010related side effects, especially gastrointestinal relevance, was significantly reduced with ZJP. Therefore, rational concomitant use of VEN and ZJP might have low risk of HDI and be promising in clinical practice.<\/jats:p>","DOI":"10.1111\/bcpt.13713","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T03:09:53Z","timestamp":1644289793000},"page":"522-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Zuojin Pill (<i>Rhizoma Coptidis<\/i>and<i>Fructus Evodiae<\/i>preparation) on the pharmacokinetics and side effects of venlafaxine in humans"],"prefix":"10.1111","volume":"130","author":[{"given":"Dongmin","family":"Yan","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Pharmacokinetics, Institute of Clinical Pharmacology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 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