{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:33:45Z","timestamp":1788212025661,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Metabolic abnormalities have been associated with olanzapine treatment. We assessed if olanzapine has dose\u2010dependent effects on metabolic parameters with changes for weight, blood pressure, lipid and glucose profiles being modelled using linear mixed\u2010effects models. The risk of metabolic abnormalities including early weight gain (EWG) (\u22655% during first month) was assessed using mixed\u2010effects logistic regression models. In 392 olanzapine\u2010treated patients (median age 38.0\u00a0years, interquartile range [IQR]\u2009=\u200926.0\u201353.3, median dose 10.0\u00a0mg\/day, IQR\u2009=\u00a05.0\u201310.0 for a median follow\u2010up duration of 40.0\u00a0days, IQR\u2009=\u200920.7\u2013112.2), weight gain was not associated with olanzapine dose (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.61) although it was larger for doses versus \u226410\u00a0mg\/day (2.54\u2009\u00b1\u00a05.55 vs. 1.61\u2009\u00b1\u00a04.51% respectively,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.01). Treatment duration and co\u2010prescription of &gt;2 antipsychotics, antidepressants, benzodiazepines and\/or antihypertensive agents were associated with larger weight gain (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). Lower doses were associated with increase in total and HDL cholesterol and systolic and diastolic blood pressure (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05), whereas higher doses were associated with glucose increases (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.01). Patients receiving &gt;10\u00a0mg\/day were at higher EWG risk (odds risk: 2.15, 1.57\u20132.97). EWG might be prominent in high\u2010dose olanzapine\u2010treated patients with treatment duration and co\u2010prescription of other medications being weight gain moderators. The lack of major dose\u2010dependent patterns for weight gain emphasizes that olanzapine\u2010treated patients are at weight gain risk regardless of the dose.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.13715","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T23:58:46Z","timestamp":1644623926000},"page":"531-541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Olanzapine\u2010associated dose\u2010dependent alterations for weight and metabolic parameters in a prospective cohort"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-4117","authenticated-orcid":false,"given":"Georgios","family":"Schoretsanitis","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics Hospital of Psychiatry, University of Zurich  Zurich Switzerland"},{"name":"Department of Psychiatry, Northwell Health The Zucker Hillside Hospital  New York New York USA"},{"name":"Department of Psychiatry Zucker School of Medicine at Northwell\/Hofstra  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Dubath","sequence":"additional","affiliation":[{"name":"Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neuroscience, Department of Psychiatry Lausanne University Hospital, University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Grosu","sequence":"additional","affiliation":[{"name":"Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neuroscience, Department of Psychiatry Lausanne University Hospital, University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Piras","sequence":"additional","affiliation":[{"name":"Unit of Pharmacogenetics and 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Center for Psychiatric Neuroscience, Department of Psychiatry Lausanne University Hospital, University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Crettol","sequence":"additional","affiliation":[{"name":"Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neuroscience, Department of Psychiatry Lausanne University Hospital, University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neuroscience, Department of Psychiatry Lausanne University Hospital, University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Gamma","sequence":"additional","affiliation":[{"name":"Les Toises Psychiatry and 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