{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:44:28Z","timestamp":1747183468166,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014305","name":"HIV Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014305","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The influence of composite <jats:italic>CYP2B6*6\/*18<\/jats:italic> genotype on trough plasma nevirapine levels, HIV RNA levels (virologic response) and CD4+ T lymphocyte and absolute lymphocyte counts (immunologic response) of HIV\u2010infected patients were evaluated. Patients with records of trough plasma nevirapine levels, CD4+ T lymphocyte, absolute lymphocyte and viral load counts at baseline and months 6 and 12 after initiation of nevirapine\u2010based antiretroviral therapy combinations were retrospectively analysed. Participants were from a cohort of 150 patients previously genotyped and with measured plasma nevirapine levels. Relationship between genotype and nevirapine levels, absolute lymphocyte and CD4+ T lymphocyte counts and viral load were explored. Composite <jats:italic>CYP2B6*6\/*18<\/jats:italic> genotype was significantly associated with trough plasma nevirapine levels (geometric mean [standard deviation]: 4482\u2009ng\/ml [1349] of normal metabolizers vs. 4632\u2009ng\/ml [1793] of intermediate metabolizers vs. 6229\u2009ng\/ml [2549] of poor metabolizers; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), but not the plasma HIV RNA levels, absolute lymphocyte and CD4+ T lymphocyte counts. Overall, immunologic response showed improvement with approximately 61.3% and 70.4% of patients with CD4+ T lymphocyte count &gt;350 cells\/mm<jats:sup>3<\/jats:sup> at months 6 and 12 therapy duration respectively compared to 23.1% at baseline. Composite <jats:italic>CYP2B6*6\/*18<\/jats:italic> genotype correlated with plasma nevirapine levels but not immunologic and virologic responses.<\/jats:p>","DOI":"10.1111\/bcpt.13737","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:39:33Z","timestamp":1651203573000},"page":"45-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trough plasma nevirapine levels, immunologic and virologic responses in composite <i>CYP2B6*6\/*18<\/i> HIV\u2010infected adult Nigerian patients"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6868-8687","authenticated-orcid":false,"given":"Sa'ad T.","family":"Abdullahi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Medicinal Chemistry University of Ilorin  Ilorin Nigeria"},{"name":"Department of Pharmaceutical Chemistry Obafemi Awolowo University  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7483","authenticated-orcid":false,"given":"Julius O.","family":"Soyinka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Obafemi Awolowo University  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2782-7190","authenticated-orcid":false,"given":"Rahman A.","family":"Bolarinwa","sequence":"additional","affiliation":[{"name":"Department of Haematology Obafemi Awolowo University Teaching Hospitals Complex  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olusola J.","family":"Olarewaju","sequence":"additional","affiliation":[{"name":"Department of Haematology Obafemi Awolowo University Teaching Hospitals Complex  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alakija K.","family":"Salami","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ilorin Teaching Hospital  Ilorin Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moji T.","family":"Bakare\u2010Odunola","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Medicinal Chemistry University of Ilorin  Ilorin Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010065X.1989.tb00021.x"},{"volume-title":"Molecular Biology of the Cell","year":"2002","author":"Alberts B","key":"e_1_2_10_3_1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/417095a"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12066"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/319755"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1993.tb38771.x"},{"volume-title":"Harrisons Principles of Internal Medicine","year":"2005","author":"Fauci AS","key":"e_1_2_10_8_1"},{"volume-title":"StatPearls","year":"2020","author":"Li R","key":"e_1_2_10_9_1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e32835b8123"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/24.5.286"},{"volume-title":"Committee on Social Security HIV Disability Criteria. 3, Low CD4 Count as an Indicator of Disability. 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