{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:43:08Z","timestamp":1784266988274,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","award":["18\u201010\u20100527"],"award-info":[{"award-number":["18\u201010\u20100527"]}],"id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["18\u2010B\u20100225I"],"award-info":[{"award-number":["18\u2010B\u20100225I"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tramadol is a commonly used opioid with a potential of addiction and abuse. Using Danish nationwide registers, we aimed to (1) characterise opioid poisonings; (2) assess the 30\u2010day mortality following morphine, oxycodone, and mixed poisonings compared to tramadol poisonings; and (3) assess the development in tramadol poisonings during a 12\u2010year period.<\/jats:p><jats:p>Poisonings were identified from 2006 to 2017. A Cox proportional hazards regression model was used to estimate adjusted hazard ratios (aHRs) along with 95% confidence intervals (CIs) for 30\u2010day mortality following morphine, oxycodone or mixed poisonings compared to tramadol poisonings.<\/jats:p><jats:p>We identified 7718 opioid poisonings among 6365 patients. The patients with a tramadol poisoning were younger and had less comorbidities than the patients with a morphine, oxycodone or mixed poisoning. Within 30\u2009days, a total of 205 patients died. The 30\u2010day mortality risk was higher following morphine (aHR 3.2, 95% CI 2.0\u20135.1), oxycodone (aHR 2.1, 95% CI 1.2\u20133.6) and mixed poisonings (aHR 1.6, 95% CI 1.0\u20132.7) compared to tramadol poisonings. The annual number of tramadol poisonings increased from 233 in 2006 to 501 in 2013 and declined to 348 in 2017.<\/jats:p><jats:p>In conclusion, despite a lower mortality risk compared to other opioid poisonings, physicians should consider the poisoning and abuse risks when prescribing tramadol.<\/jats:p>","DOI":"10.1111\/bcpt.13741","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T07:40:21Z","timestamp":1652254821000},"page":"83-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Short\u2010term mortality following tramadol poisonings in Denmark"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7399-8228","authenticated-orcid":false,"given":"Anne Mette Skov","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Petersen","sequence":"additional","affiliation":[{"name":"Copenhagen Phase IV unit (Phase4CPH), Department of Clinical Pharmacology and Center of Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Section of Biostatistics, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel Bring","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid Blicher","family":"Schelde","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon Tr\u00e6rup","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Espen","family":"Jimenez Solem","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Copenhagen Phase IV unit (Phase4CPH), Department of Clinical Pharmacology and Center of Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9974-2738","authenticated-orcid":false,"given":"Tonny Studsgaard","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.09.018"},{"issue":"26","key":"e_1_2_8_3_1","first-page":"V01170077","article-title":"Potential pharmacological consequences of the development of the opioid consumption in Denmark","volume":"179","author":"Christrup L","year":"2017","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010199346020\u201000008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2012.735216"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010020\u201003016\u20106"},{"issue":"127","key":"e_1_2_8_7_1","first-page":"37623","article-title":"Schedule of controlled substances: placement of tramadol into schedule IV. 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