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The involvement of ion channels in the pathogenesis of migraine gathered considerable attention with the findings that different ion channels subfamilies are expressed in trigeminovascular system, the physiological substrate of migraine pain, and several ion channel openers investigated in clinical trials with diverse primary endpoints caused headache as a frequent side effect. High\u2010conductance (big) calcium\u2010activated potassium (BK<jats:sub>Ca<\/jats:sub>) channel is expressed in the cranial arteries and the trigeminal pain pathway. Recent clinical research revealed that infusion of BK<jats:sub>Ca<\/jats:sub> channel opener MaxiPost caused vasodilation, headache and migraine attack. 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