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PM<jats:sub>2.5<\/jats:sub> exaggerate adipose inflammation and insulin resistance in mice with diet\u2010induced obesity. Here, we elucidate the hypothesis that such systemic effects may be triggered by adhered particle components affecting adipose tissue directly. Studying adipocytes differentiated from primary human mesenchymal stem cells, we found that lipophilic organic chemicals (OC) from diesel exhaust particles induced inflammation\u2010associated genes and increased secretion of the chemokine CXLC8\/interleukin\u20108 as well as matrix metalloprotease 1. The oxidative stress response gene haem oxygenase\u20101 and tumour necrosis factor alpha were seemingly not affected, while aryl hydrocarbon receptor\u2010regulated genes, cytochrome P450 1A1 (CYP1A1) and CYP1B1 and plasminogen activator inhibitor\u20102, were clearly up\u2010regulated. Finally, expression of \u03b2\u2010adrenergic receptor, known to regulate adipocyte homoeostasis, was down\u2010regulated by exposure to these lipophilic OC. Our results indicate that low concentrations of OC from combustion particles have the potential to modify expression of genes in adipocytes that may be linked to metabolic disease. Further studies on mechanisms linking PM exposure and metabolic diseases are warranted.<\/jats:p>","DOI":"10.1111\/bcpt.13805","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T13:55:31Z","timestamp":1665410131000},"page":"83-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8023-1148","authenticated-orcid":false,"given":"Bendik C.","family":"Brinchmann","sequence":"first","affiliation":[{"name":"Department of Air Pollution and Noise, Domain of Infection Control, Environment and Health Norwegian Institute of Public Health  Oslo Norway"},{"name":"Department of Occupational Medicine and Epidemiology National Institute of Occupational Health  Oslo 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