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The nephroprotective effect of Berberine (BBR), a herbal ingredient, is well documented as antioxidant and activation of the Nrf2 signalling. This study aimed to investigate if Nrf2 is a major protective mechanism of BBR in DOX animal models. Rats were divided as (<jats:italic>n<\/jats:italic>\u2009=\u20096 each): Control, BBR (100\u2009mg\/kg, orally), DOX (15\u2009mg\/kg, orally), BBR\u2009+\u2009DOX, and BBR\u2009+\u2009DOX\u2009+\u2009brusatol (0.2\u00a0mg\/kg, i.p.\/twice per week) (an Nrf2 inhibitor). DOX was given as a single dose (day 10), whereas BBR was administered for 3\u00a0weeks on a daily basis. BBR reduced tubular degeneration and improved renal markers in DOX\u2010treated rats. It also reduced renal nuclear levels of NF\u2010\u03baB p65, total reactive oxygen species (ROS), lipid peroxides, interleukin\u20106 (IL\u20106), and tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), as well as mRNA levels of Bax and cleaved caspase\u20103. However, BBR stimulated glutathione (GSH) and superoxide dismutase (SOD) levels, the transcription of Bcl2, and the mRNA, total cytoplasmic, and nuclear levels of Nrf2 with no effect on the cytoplasmic keap1 levels. All these effects disappeared by brusatol. In conclusion, BBR prevents DOX\u2010induced renal damage by activating Nrf2.<\/jats:p>","DOI":"10.1111\/bcpt.13807","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T07:19:11Z","timestamp":1665559151000},"page":"98-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The protection afforded by Berberine against chemotherapy\u2010mediated nephropathy in rats involves regulation of the antioxidant axis"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-1574","authenticated-orcid":false,"given":"Reham I.","family":"Alagal","sequence":"first","affiliation":[{"name":"Department of Health Sciences, College of Health and Rehabilitation Sciences Princess Nourah Bint Abdulrahman University  Riyadh P.O.Box 84428 11671 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-5725","authenticated-orcid":false,"given":"Nora A.","family":"AlFaris","sequence":"additional","affiliation":[{"name":"Nutrition and Food Science (PHD), Department of Physical Sport Science Princess Nourah bint Abdulrahman University  Riyadh P.O.Box 84428 11671 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghedeir M.","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, College of Food and Agricultural Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozaa Z.","family":"ALTamimi","sequence":"additional","affiliation":[{"name":"Nutrition and Food Science (PHD), Department of Physical Sport Science Princess Nourah bint Abdulrahman University  Riyadh P.O.Box 84428 11671 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujain A.","family":"AlMousa","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, College of Health and Rehabilitation Sciences Princess Nourah Bint Abdulrahman University  Riyadh P.O.Box 84428 11671 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Abdo","family":"Yahya","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, College of Food and Agricultural Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/POR.S97310"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.14745"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10924"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2013.79"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155218798157"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374\u2010019\u20100193\u20101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.09.059"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212486"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010020\u201004203\u2010z"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360\u2010021\u201000494\u2010x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127090"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.08.012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111308"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2017.01.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8841726"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.07.011"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e05985"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.03.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.241463"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO02429H"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e03803"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.09.003"},{"key":"e_1_2_8_24_1","unstructured":"SteeleJF OsawaM.Gender diversity and tohoku reconstruction: Governance challenges and opportunities two years on. 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