{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:31:00Z","timestamp":1791433860675,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004472","name":"Riksbankens Jubileumsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004472","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Use of benzodiazepines (BZ) and related drugs is subject to considerable debate due to problems with dependency and adverse events. We aimed to describe and compare their use across the Nordic countries. Data on the use of clonazepam, BZ\u2010sedatives, BZ\u2010hypnotics, and benzodiazepine\u2010related drugs (BZRD) in adults (\u226520\u2009years) were obtained from nationwide registers in Denmark, Finland, Iceland, Norway, and Sweden, 2000\u20132020. Main measures were therapeutic intensity (TI:DDD\/1000 inhabitants [inhab.]\/day) and annual prevalence (users\/1000 inhab.\/year). Overall, TI of BZ and related drugs decreased in all Nordic countries from 2004 to 2020. However, there were considerable differences between countries in TI. In 2020, the TI of BZ and related drugs ranged from 17 DDD\/1000 inhab.\/day in Denmark to 93 DDD\/1000 inhab.\/day in Iceland. BZRD accounted for 55\u201378% of BZ use in 2020, followed by BZ sedatives at 20\u201344%, BZ\u2010hypnotics at &lt;1\u20135%, and clonazepam at &lt;1\u20132%. Annual prevalence of BZ use increased with age in all countries, and the highest annual prevalence was observed among people \u226580\u2009years. Overall, the use of BZ and related drugs has decreased in all Nordic countries from 2004 to 2020, however, with considerable differences in their use between countries. The highest prevalence was observed among the oldest age groups\u2014despite warnings against their use in this population.<\/jats:p>","DOI":"10.1111\/bcpt.13811","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T05:49:42Z","timestamp":1667195382000},"page":"60-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Use of benzodiazepines and benzodiazepine\u2010related drugs in the Nordic countries between 2000 and 2020"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5786-5203","authenticated-orcid":false,"given":"Mikkel","family":"H\u00f8jlund","sequence":"first","affiliation":[{"name":"Department of Public Health, Clinical Pharmacology, Pharmacy, and Environmental Medicine University of Southern Denmark  Odense Denmark"},{"name":"Department of Psychiatry Aabenraa Mental Health Services Region of Southern Denmark  Aabenraa Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4660-1111","authenticated-orcid":false,"given":"Larus S.","family":"Gudmundsson","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of Iceland  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0656-6905","authenticated-orcid":false,"given":"Jacob H.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Public Health, Clinical Pharmacology, Pharmacy, and Environmental Medicine University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0887-0137","authenticated-orcid":false,"given":"Leena K.","family":"Saastamoinen","sequence":"additional","affiliation":[{"name":"Research Unit The Social Insurance Institution of Finland (Kela)  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0761-9028","authenticated-orcid":false,"given":"Helga","family":"Zoega","sequence":"additional","affiliation":[{"name":"School of Population Health, Faculty of Medicine and Health University of New South Wales  Sydney Australia"},{"name":"Centre of Public Health Sciences, Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7525-9701","authenticated-orcid":false,"given":"Svetlana O.","family":"Skurtveit","sequence":"additional","affiliation":[{"name":"Department of Mental Disorders The Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-4319","authenticated-orcid":false,"given":"Jonas W.","family":"Wastesson","sequence":"additional","affiliation":[{"name":"Ageing Research Center Karolinska Institutet &amp; Stockholm University  Stockholm Sweden"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-8708","authenticated-orcid":false,"given":"Jesper","family":"Hallas","sequence":"additional","affiliation":[{"name":"Department of Public Health, Clinical Pharmacology, Pharmacy, and Environmental Medicine University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-5679","authenticated-orcid":false,"given":"Anton","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Public Health, Clinical Pharmacology, Pharmacy, and Environmental Medicine University of Southern Denmark  Odense Denmark"},{"name":"Hospital Pharmacy Funen Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.357"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512\u2010200825010\u201000007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174730"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38623.768588.47"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.11.011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.03.009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6231"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000524400"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2015.09.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2217"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurger.2012.04.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12626"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4551"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000080"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010036860"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.21.0659"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw213"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u20107843.2009.00494.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201051455\u20106_17"},{"issue":"2","key":"e_1_2_8_22_1","first-page":"129","article-title":"Establishment of the nationwide Norwegian prescription database (NorPD)\u2014new opportunities for research in pharmacoepidemiology in Norway","volume":"18","author":"Furu K","year":"2008","journal-title":"Norsk Epidemiologi"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1294"},{"key":"e_1_2_8_24_1","unstructured":"WHOCC \u2010 ATC\/DDD Index. 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