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Here, our aim was to analyse the safety of calcipotriol for cartilage and bone in alleviated\u2010dose (0.1\u2009mg instead of usual \u22651mg dose) zymosan\u2010induced arthritis in rats. Theoretically, high doses of vitamin D or analogues could have detrimental effects on bone or cartilage. The rats were divided into four groups: vehicle (n\u2009=\u20099), dexamethasone 0.1\u2009mg\/kg (n\u2009=\u20099), calcipotriol 0.1\u2009mg\/kg (n\u2009=\u20098) and negative control (n\u2009=\u200910) with no injections. Arthritic rats were given phosphate\u2010buffered saline (PBS) injections to left knees as a control. After euthanasia on day 8, all knees were imaged with micro\u2010computed tomography for surface lesions and decalcified for histological analyses. Contrary to our expectations, no significant changes could be observed in the tomography data and histological scores among the three treatment groups or between the vehicle\u2010treated and non\u2010arthritic group. Calcipotriol did not cause adverse effects on cartilage or subchondral bone within a week, suggesting that it could be safely used in local treatment of arthritis. The alleviated model caused synovitis with local and systemic inflammatory response without cartilage erosions, which might be useful in studying self\u2010limiting synovitis where cartilage or bone effects are not of primary interest.<\/jats:p>","DOI":"10.1111\/bcpt.13815","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T13:52:25Z","timestamp":1668779545000},"page":"131-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["No adverse effects on periarticular tissue by intra\u2010articular vitamin D analogue calcipotriol in a reduced\u2010dose zymosan\u2010induced arthritis model in rats"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-3740","authenticated-orcid":false,"given":"Jere","family":"Huovinen","sequence":"first","affiliation":[{"name":"Cancer and Translational Medicine Research Unit, Medical Research Center Oulu Oulu 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