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Berberine and pulmonary fibrosis prediction targets were collected for Gene Ontology (GO) functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and so forth. A single intranasal dose of BLM (2.5\u2009mg\/kg) was administered to establish a model of fibrosis after lung injury, and berberine (50\u2009mg\/kg) was administered intraperitoneally daily for treatment. Network pharmacology results suggested that the mitogen\u2010activated protein kinase (MAPK) signalling pathway may be a potential mechanism of berberine in delaying pulmonary fibrosis. The results of animal experiments showed that compared with the BLM group, after 14\u2009days of berberine treatment, lung inflammatory cell aggregation was reduced and the expression levels of tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin (IL)\u20108 and IL\u20106 were down\u2010regulated in mice (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); after 42\u2009days of berberine treatment, the expression levels of transforming growth factor (TGF)\u2010\u03b21, platelet\u2010derived growth factor\u2010AB (PDGF\u2010AB), hydroxyproline (HYP) and \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) were significantly down\u2010regulated (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and the expression levels of total p38 MAPK\u03b1 and p38 MAPK\u03b1 (pT180\/Y182) were down\u2010regulated also (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), inhibited collagen production and deposition, and increased the survival rate of mice to 70%. In conclusion, berberine attenuated inflammation mice, inhibited collagen production and showed some anti\u2010pulmonary fibrosis potential in the MAPK signalling pathway.<\/jats:p>","DOI":"10.1111\/bcpt.13818","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T18:31:38Z","timestamp":1669487498000},"page":"154-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Berberine regulates pulmonary inflammatory microenvironment and decreases collagen deposition in response to bleomycin\u2010induced pulmonary fibrosis in mice"],"prefix":"10.1111","volume":"132","author":[{"given":"Zheng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases First Affiliated Hospital of Baotou Medical College  Baotou 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