{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:43:25Z","timestamp":1787064205110,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803832"],"award-info":[{"award-number":["81803832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acetaminophen (APAP)\u2010induced liver injury (AILI) has been recognized as a pivotal contributor to drug\u2010induced liver failure in Western countries, but its molecular mechanism remains poorly understood. Growth differentiation factor 15 (GDF15) is a pleiotropic factor that alleviates non\u2010alcoholic liver steatohepatitis, liver fibrosis and liver injury. The aim of the present study was to examine the possibility whether GDF15 confers protection against AILI. We found that the gene expression of\n                    <jats:italic>Gdf15<\/jats:italic>\n                    was increased significantly after APAP overdose in mice. Next, the role of\n                    <jats:italic>Gdf15<\/jats:italic>\n                    in AILI was evaluated by hepatic\n                    <jats:italic>Gdf15<\/jats:italic>\n                    overexpression (using adeno\u2010associated virus serotype 8), injection with recombinant human GDF15 (rhGDF15) and\n                    <jats:italic>Gdf15<\/jats:italic>\n                    knockout mice after challenge with APAP. A marked elevation of\n                    <jats:italic>Gdf15<\/jats:italic>\n                    was observed after AILI. However, there were no significant differences in AILI\u2010related liver injury and JNK phosphorylation after\n                    <jats:italic>Gdf15<\/jats:italic>\n                    overexpression, rhGDF15 injection or\n                    <jats:italic>Gdf15<\/jats:italic>\n                    deficiency. Together, we conclude that, despite a noticeable elevation of\n                    <jats:italic>Gdf15<\/jats:italic>\n                    level after AILI,\n                    <jats:italic>Gdf15<\/jats:italic>\n                    is dispensable for APAP\u2010induced AILI. Our study further suggests that genomic analysis of mRNA expression after APAP overdose is of limited relevance unless followed up by a functional analysis of candidate genes in vivo.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.13834","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T06:53:59Z","timestamp":1672901639000},"page":"341-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Growth differentiation factor 15 is dispensable for acetaminophen\u2010induced liver injury in mice"],"prefix":"10.1111","volume":"132","author":[{"given":"Peng","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Clinical Research Hospital of Chinese Academy of Sciences (Hefei) University of Science and Technology of China  Hefei 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 Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Clinical Research Hospital of Chinese Academy of Sciences (Hefei) University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Clinical Research Hospital of Chinese Academy of Sciences (Hefei) University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre for 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