{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:14:40Z","timestamp":1793240080422,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cyclopeptide mushroom poisoning is responsible for 90%\u201395% of deaths from macrofungi ingestion. The main objectives of this study are to describe cases of cyclopeptide mushroom poisoning and to determine risk factors that may influence the severity\/mortality of poisoned patients. We included all cases of amatoxin toxicity reported to two French Poison Centers from 2013 through 2019. We compared the severity with the Poison Severity Score (PSS) and the outcomes of patients using simple logistic regression and multinomial logistic regression. We included 204 cases of amatoxin toxicity. More than three\u2010quarters developed an increase in AST and\/or ALT (78.1%), and over half developed a decrease in prothrombin ratio (&lt;70%: 53%) and\/or Factor V (&lt;70%: 54%). One\u2010third developed an acute renal injury (AKI). Twelve patients (5.9%) developed post\u2010poisoning sequelae (persistent kidney injury more than 1\u2009month after ingestion and liver transplant). Five patients (2.5%) received a liver transplant, and nine died (4.4%). The mean time to onset of digestive disorders was shorter in PSS2 and PSS3\u20134 patients (10.9\u2009\u00b1\u20093.9\/11.3\u2009\u00b1\u20096.3\u00a0h) than in PSS1 patients (14\u2009\u00b1\u20096.5\u00a0h; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Patients who died or developed post\u2010poisoning sequelae had more frequent cardiovascular comorbidities compared with recovered patients (60.0% <jats:italic>versus<\/jats:italic> 29.5%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p>","DOI":"10.1111\/bcpt.13858","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:10:40Z","timestamp":1678684240000},"page":"528-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cyclopeptide mushroom poisoning: A retrospective series of 204 patients"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0593-772X","authenticated-orcid":false,"given":"J\u00e9r\u00e9my","family":"Lecot","sequence":"first","affiliation":[{"name":"Poison Control Center Angers University Hospital (CHU Angers)  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Cellier","sequence":"additional","affiliation":[{"name":"Poison Control Center Angers University Hospital (CHU Angers)  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Courtois","sequence":"additional","affiliation":[{"name":"Poison Control Center Bordeaux University Hospital (CHU Bordeaux)  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Vodovar","sequence":"additional","affiliation":[{"name":"Poison Control Center, Fernand\u2010Widal\u2010Lariboisiere Hospital, APHP Federation of Toxicology APHP  Paris France"},{"name":"UFR medicine Paris University  Paris 75010 France"},{"name":"Faculty of Pharmacy INSERM UMRS 1144  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Le Roux","sequence":"additional","affiliation":[{"name":"Poison Control Center Angers University Hospital (CHU Angers)  Angers France"},{"name":"University of Angers, CHU Angers, University of Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2010 UMR_S1085  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Landreau","sequence":"additional","affiliation":[{"name":"Faculty of Health Angers University  Angers France"},{"name":"Univ Angers, Univ Brest, IRF, SFR ICAT  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Labadie","sequence":"additional","affiliation":[{"name":"Poison Control Center Bordeaux University Hospital (CHU Bordeaux)  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Bruneau","sequence":"additional","affiliation":[{"name":"Poison Control Center Angers University Hospital (CHU Angers)  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Descatha","sequence":"additional","affiliation":[{"name":"Poison Control Center Angers University Hospital (CHU Angers)  Angers France"},{"name":"University of Angers, CHU Angers, University of Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2010 UMR_S1085  Angers France"},{"name":"Department of Occupational Medicine, Epidemiology and Prevention Donald and Barbara Zucker School of Medicine, Hofstra\/Northwell  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112802273353"},{"key":"e_1_2_8_3_1","first-page":"666","article-title":"Surveillance nationale des intoxications alimentaires par des champignons: bilan des cas rapport\u00e9s au r\u00e9seau des centres antipoison de 2010 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