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Nevertheless, no clear consensus can be found as to whether vitamin D affects COVID\u201019 disease burden. Some studies found that vitamin D levels and\/or vitamin D supplementation alleviated COVID\u201019 disease severity and mortality. Contrarily, other studies found no such effects of vitamin D. To understand this lack of consensus, it is relevant to investigate molecular studies of the vitamin D receptor (VDR), as such studies might explain apparent controversies. We have investigated recent studies of how transcriptional regulation by the VDR affects the immune response against SARS\u2010CoV\u20102. One study found that cells from severe COVID\u201019 patients displayed a dysregulated vitamin D response. Contrarily, another study observed a normal immune response towards SARS\u2010CoV\u20102 in a patient with a non\u2010functional VDR. These observations indicate that hypovitaminosis D is not a prerequisite for an efficient immune response against SARS\u2010CoV\u20102 and therefore not a driving factor for developing severe COVID\u201019. However, should a patient develop severe COVID\u201019, vitamin D seems to be beneficial potentially by dampening the cytokine storm.<\/jats:p>","DOI":"10.1111\/bcpt.13872","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T03:20:52Z","timestamp":1681183252000},"page":"6-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin D and SARS\u2010CoV\u20102"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-4416","authenticated-orcid":false,"given":"Sofie\u2010Louise","family":"Feentved \u00d8dum","sequence":"first","affiliation":[{"name":"The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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