{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T20:02:19Z","timestamp":1759694539392,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current study was aimed to investigate the beneficial effect of sumatriptan, a 5\u2010hydroxytryptamine 1B\/1D (5HT<jats:sub>1B\/1D<\/jats:sub>) receptor agonist, on gastric ulcer in rats via stimulating 5HT<jats:sub>1B\/1D<\/jats:sub> receptors and suppressing pro\u2010inflammatory cytokines. Rats were allocated into three models of gastric ulcer: indomethacin (30\u2009mg\/kg, PO), water immersion restraint stress (WRS) and ethanol (5\u00a0ml\/kg PO). Animals were administered with sumatriptan (0.01, 0.1, 0.3 and 1\u00a0mg\/kg, i.p) 30\u2009min before gastric ulcer induction. GR\u2010127935 (0.01\u2009mg\/kg, i.p, a selective 5HT<jats:sub>1B\/1D<\/jats:sub> antagonist) was administered 30\u2009min before sumatriptan (0.1\u00a0mg\/kg) injection. Macroscopic assessments (J\u2010score), ELISA analysis of tumour necrosis factor\u2010alpha (TNF\u2010\u03b1) and interleukin\u20101beta (IL\u20101\u03b2) and histopathological changes were performed on the rat's stomach tissues. Gastric ulcer induction in three models caused an increase in J\u2010score, TNF\u2010\u03b1, IL\u20101\u03b2 and microscopic features. Sumatriptan (0.1\u00a0mg\/kg) significantly improved gastric injury induced by indomethacin, WRS and ethanol through the reduction in the J\u2010score, TNF\u2010\u03b1, IL\u20101\u03b2 and microscopic lesions. Concurrent administration of GR\u2010127935 (0.01\u2009mg\/kg) with sumatriptan (0.1\u00a0mg\/kg) reversed the gastroprotective effect of sumatriptan in three models. Sumatriptan possessed gastroprotective effects on indomethacin\u2010, WRS\u2010 and ethanol\u2010induced gastric damage in rats via the possible involvement of the 5HT<jats:sub>1B\/1D<\/jats:sub> receptors.<\/jats:p>","DOI":"10.1111\/bcpt.13905","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T07:33:35Z","timestamp":1685432015000},"page":"156-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gastroprotective effect of sumatriptan against indomethacin\u2010, stress\u2010 and ethanol\u2010induced gastric damage in male rats: Possible modulatory role of 5\u2010hydroxytryptamine 1B\/1D receptors and pro\u2010inflammatory cytokines"],"prefix":"10.1111","volume":"133","author":[{"given":"Aysa","family":"Ostovaneh","sequence":"first","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of 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