{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:52:54Z","timestamp":1788519174113,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inhalation studies are the gold standard for assessing the toxicity of airborne materials. They require considerable time, special equipment, and large amounts of test material. Intratracheal instillation is considered a screening and hazard assessment tool as it is simple, quick, allows control of the applied dose, and requires less test material. The particle\u2010induced pulmonary inflammation and acute phase response in mice caused by intratracheal instillation or inhalation of molybdenum disulphide or tungsten particles were compared. End points included neutrophil numbers in bronchoalveolar lavage fluid,\n                    <jats:italic>Saa3<\/jats:italic>\n                    mRNA levels in lung tissue and\n                    <jats:italic>Saa1<\/jats:italic>\n                    mRNA levels in liver tissue, and SAA3 plasma protein. Acute phase response was used as a biomarker for the risk of cardiovascular disease. Intratracheal instillation of molybdenum disulphide or tungsten particles did not produce pulmonary inflammation, while molybdenum disulphide particles induced pulmonary acute phase response with both exposure methods and systemic acute phase response after intratracheal instillation. Inhalation and intratracheal instillation showed similar dose\u2013response relationships for pulmonary and systemic acute phase response when molybdenum disulphide was expressed as dosed surface area. Both exposure methods showed similar responses for molybdenum disulphide and tungsten, suggesting that intratracheal instillation can be used for screening particle\u2010induced acute phase response and thereby particle\u2010induced cardiovascular disease.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.13915","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T23:19:20Z","timestamp":1686698360000},"page":"265-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of acute phase response in mice after inhalation and intratracheal instillation of molybdenum disulphide and tungsten particles"],"prefix":"10.1111","volume":"133","author":[{"given":"Claudia Torero","family":"Gutierrez","sequence":"first","affiliation":[{"name":"Section of Environmental Health, Department of Public Health University of Copenhagen  Copenhagen Denmark"},{"name":"National Research Centre for the Working Environment  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charis","family":"Loizides","sequence":"additional","affiliation":[{"name":"Climate and Atmosphere Research Centre The Cyprus Institute  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iosif","family":"Hafez","sequence":"additional","affiliation":[{"name":"Climate and Atmosphere Research Centre The Cyprus Institute  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Biskos","sequence":"additional","affiliation":[{"name":"Climate and Atmosphere Research Centre The Cyprus Institute  Nicosia Cyprus"},{"name":"Faculty of Civil Engineering and Geosciences Delft University of Technology  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Loeschner","sequence":"additional","affiliation":[{"name":"Research Group for Analytical Food Chemistry, National Food Institute Technical University of Denmark  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Brostr\u00f8m","sequence":"additional","affiliation":[{"name":"National Research Centre for the Working Environment  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Roursgaard","sequence":"additional","affiliation":[{"name":"Section of Environmental Health, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Thoustrup","family":"Saber","sequence":"additional","affiliation":[{"name":"National Research Centre for the Working Environment  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Section of Environmental Health, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorid Birkelund","family":"S\u00f8rli","sequence":"additional","affiliation":[{"name":"National Research Centre for the Working Environment  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Hadrup","sequence":"additional","affiliation":[{"name":"National Research Centre for the Working Environment  Copenhagen Denmark"},{"name":"Research Group for Risk\u2010Benefit, National Food Institute Technical University of Denmark  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6807-1524","authenticated-orcid":false,"given":"Ulla","family":"Vogel","sequence":"additional","affiliation":[{"name":"National Research Centre for the Working Environment  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20108977\u201011\u20105"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.05.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2015.1104740"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b05652"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989\u2010020\u201000369\u20109"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj123"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17020165"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201907476"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1279"},{"key":"e_1_2_8_11_1","unstructured":"National Research Centre for the Working Environment.Zinc oxide: scientific basis for setting a health\u2010based occupational exposure limit. 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