{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:44:52Z","timestamp":1747183492136,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2020ZX09201022"],"award-info":[{"award-number":["2020ZX09201022"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drugs for acute postoperative pain and breakthrough cancer pain are still urgent in clinical. LPM3480392 is a G\u2010protein\u2010biased ligand at the \u03bc\u2010opioid receptor and showed potent analgesia in nonclinical studies. Two phase I studies of LPM3480392 were conducted in healthy Chinese male volunteers to explore its tolerability, pharmacokinetics and pharmacodynamics under single ascending doses (Study I 0.1\u20133.0\u00a0mg, 30\u2009min) and different infusion times (Study II, 0.6\u20131.0\u00a0mg, 2\u201315\u2009min). There was one serious adverse event (AE) observed in Study II, and the rest AEs were mild or moderate in severity and resolved by the end of the study. Plasma LPM3480392 maximum concentration (C<jats:sub>max<\/jats:sub>) (under lower infusion rate) and area under the plasma concentration\u2010time curve (AUCs) were generally increased with dose. Moreover, LPM3480392 at a dose of 0.6\u00a0mg under a 2\u00a0min infusion rate elicited effective analgesia as the peak effect within 10\u201330\u2009min, which was measured by cold pain test and pupillometry. These findings suggest that LPM3480392 could be a potential treatment for acute pain management.<\/jats:p>","DOI":"10.1111\/bcpt.13937","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:57:48Z","timestamp":1693195068000},"page":"592-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacokinetics, pharmacodynamics and safety of LPM3480392 in two phase I clinical trials in healthy Chinese male subjects"],"prefix":"10.1111","volume":"133","author":[{"given":"Dan\u2010dan","family":"Yang","sequence":"first","affiliation":[{"name":"Center of Clinical Pharmacology Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-9484","authenticated-orcid":false,"given":"Jia\u2010ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Clinical Pharmacology Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zou\u2010rong","family":"Ruan","sequence":"additional","affiliation":[{"name":"Center of Clinical Pharmacology Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center of Clinical Pharmacology Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"Center of Clinical Pharmacology Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Hu","sequence":"additional","affiliation":[{"name":"Center of Clinical Pharmacology Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Che","sequence":"additional","affiliation":[{"name":"Luye Pharmaceutical Co. 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