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The prevalence and circumstances of occurrence of such cerebral microbleeds in the severely poisoned patients are unknown. We retrospectively reviewed all cerebral MRIs performed in the poisoned patients with atypical neurological presentation or outcome admitted to our intensive care unit in 2014\u20132021. Three out of 64 patients (4.7%) investigated with cerebral MRI among the 2986 severely poisoned patients presented cerebral microbleeds. Microbleeds were localized in the white cerebral matter mainly in the corpus callosum. Ingested toxicants included dichlorvos, methadone and tramadol. Patients were found comatose with possibly prolonged severe hypoxaemia requiring prompt tracheal intubation and mechanical ventilation. They presented delayed arousal and dysexecutive syndrome leading to sequelae. Microbleeds on MRI can occur in the critically ill poisoned patients and seems to be a multifactorial phenomenon. A direct relationship with the toxicant seems improbable. Physicians should be aware of such a non\u2010specific complication accounting for sequelae.<\/jats:p>","DOI":"10.1111\/bcpt.13946","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T14:20:10Z","timestamp":1695306010000},"page":"770-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebral microbleeds in the poisoned patient: An observational magnetic resonance imaging study"],"prefix":"10.1111","volume":"133","author":[{"given":"Giulia","family":"Na\u00efm","sequence":"first","affiliation":[{"name":"Department of Medical and Toxicological Critical Care Lariboisi\u00e8re hospital  Paris France"},{"name":"INSERM UMRS\u20101144, Paris\u2010Cit\u00e9 University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Malissin","sequence":"additional","affiliation":[{"name":"Department of Medical and Toxicological Critical Care Lariboisi\u00e8re hospital  Paris France"},{"name":"INSERM UMRS\u20101144, Paris\u2010Cit\u00e9 University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-2764","authenticated-orcid":false,"given":"Bruno","family":"M\u00e9garbane","sequence":"additional","affiliation":[{"name":"Department of Medical and Toxicological Critical Care Lariboisi\u00e8re hospital  Paris France"},{"name":"INSERM UMRS\u20101144, Paris\u2010Cit\u00e9 University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","first-page":"637","article-title":"Histopathologic analysis of foci of signal loss on gradient\u2010echo T2*\u2010weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy\u2010related microbleeds","volume":"20","author":"Fazekas F","year":"1999","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000307750.41970.d9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.016289"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.1349"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613\u2010020\u201000762\u20109"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002267"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101330430"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"175","article-title":"Toxic leukoencephalopathy after inhalation of poisoned heroin: MR findings","volume":"15","author":"Tan TP","year":"1994","journal-title":"AJNR am J Neuroradiol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.55"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5897"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf257"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001227"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020202040"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2020.01.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.1238427:43\u201049"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2017.238"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.1359"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149\u2010016\u20101086\u20107"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17743670"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012673"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh253"}],"container-title":["Basic &amp; 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