{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:25:40Z","timestamp":1764433540353,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we examined the pharmacokinetics of nifedipine and investigated the maternal and foetal background factors that prolong pregnancy in pregnant women undergoing long\u2010term tocolysis. This prospective observational study included 38 pregnant women hospitalised for threatened preterm labour and treated with nifedipine extended\u2010release tablets in combination with an intravenous ritodrine infusion. Maternal plasma nifedipine concentrations were determined using high\u2010performance liquid chromatography. All patients were administered 20 or 40\u2009mg\/dose of nifedipine every 6\u00a0h at the time of blood sampling. The plasma trough concentration (C<jats:sub>trough<\/jats:sub>) was 22.6\u2009\u00b1\u200917.3\u00a0ng\/mL, the maximum plasma concentration (C<jats:sub>max<\/jats:sub>) was 30.9\u2009\u00b1\u200915.3\u00a0ng\/mL and the time to maximum concentration (T<jats:sub>max<\/jats:sub>) was 1.70\u2009\u00b1\u20091.10\u00a0h, as determined using noncompartmental analysis (NCA). The area under the curve for drug concentration (AUC<jats:sub>tau<\/jats:sub>) was 152.3\u2009\u00b1\u200991.8\u00a0mg\/L\u30fbh, and oral clearance (CL\/F) was 0.17\u2009\u00b1\u20090.08\u00a0L\/h. Using logistic regression analyses, we identified the factors that predicted term delivery from 37\u2009weeks to &lt;42\u2009weeks of gestation. Gestational age at admission and the AUC<jats:sub>tau<\/jats:sub> of nifedipine can predict term delivery. The AUC<jats:sub>tau<\/jats:sub> of nifedipine is a valuable regulatory predictor of term delivery in pregnant women undergoing long\u2010term tocolysis.<\/jats:p>","DOI":"10.1111\/bcpt.13965","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:07:05Z","timestamp":1700611625000},"page":"241-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Relationship between prolonged gestation and nifedipine pharmacokinetics in long\u2010term tocolysis"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4363-4229","authenticated-orcid":false,"given":"Miho","family":"Tamura","sequence":"first","affiliation":[{"name":"Clinical Pharmacology, Graduate School of Medicine Yamaguchi University  Ube Yamaguchi Japan"},{"name":"Pharmacy Department Yamaguchi University Hospital  Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Murata","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Yamaguchi University Hospital  Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Ota","sequence":"additional","affiliation":[{"name":"Pharmacy Department Yamaguchi University Hospital  Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Pharmacy Department Yamaguchi University Hospital  Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Arichika","sequence":"additional","affiliation":[{"name":"Pharmacy Department Yamaguchi University Hospital  Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Hakuno","sequence":"additional","affiliation":[{"name":"Pharmacy Department Yamaguchi University Hospital  Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2476-9191","authenticated-orcid":false,"given":"Naoto","family":"Okada","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Graduate School of Medicine Yamaguchi University  Ube Yamaguchi Japan"},{"name":"Pharmacy Department Yamaguchi University Hospital  Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ushijima","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutics Yamaguchi Tokyo Science University  Onoda Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutics Nihon University  Funabashi Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Graduate School of Medicine Yamaguchi University  Ube Yamaguchi Japan"},{"name":"Pharmacy Department Yamaguchi University Hospital  Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(08)60074\u20104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14951"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0b013e318199924a"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109378(11)90679\u20106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(93)90035\u2010h"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.11.038"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.583700"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP202215"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mjt.0000209679.76335.df"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.148.421"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2018.04.004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.08.030"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.1"}],"container-title":["Basic &amp; 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