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The aim of the present study was to evaluate the effect of albumin infusion on redox state and binding function of circulating albumin. We studied 20 patients with cirrhosis who routinely received albumin infusions for prevention of post\u2010paracentesis circulatory dysfunction or treatment of hepatorenal syndrome. We measured albumin fractions by redox state of cysteine\u201034 and albumin binding properties using dansylsarcosine as site II ligand. Therapeutic albumin solutions showed high contents of human nonmercaptalbumin\u20101 and human nonmercaptalbumin\u20102, exceeding the respective values in our patients with decompensated cirrhosis. An initial protocol for the first nine patients sampled at baseline, 24\u2009h and 48\u2009h after albumin infusion revealed no significant changes of oxidized albumin species or albumin binding properties. However, a modified protocol for the remaining 11 patients sampled at baseline, &lt;1\u00a0h after and 24\u2009h after albumin infusion revealed short\u2010lived changes of oxidized albumin species while no changes in albumin binding properties were observed. In conclusion, therapeutic albumin infusion transiently changed albumin redox state but did not improve binding function of circulating albumin in chronic liver failure.<\/jats:p>","DOI":"10.1111\/bcpt.13973","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T05:55:37Z","timestamp":1702533337000},"page":"375-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of albumin infusion on oxidative albumin modification and albumin binding capacity in chronic liver failure"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3687-9331","authenticated-orcid":false,"given":"Rudolf E.","family":"Stauber","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Medical University of Graz  Graz 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