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These are significant side effects caused in cancer patients treated with 5\u2010FU. In the research, 25 rats were divided into five groups, including control, 5\u2010FU and 5\u2010FU\u2009+\u20092.5, 5 and 10\u2009mg\/kg melatonin (MEL), and the protective impact of MEL against 5\u2010FU\u2010induced hepatorenal damage in rats was investigated. 5\u2010FU caused significant harm, resulting in severe renal failure and histopathological changes. It also increased BUN, creatinine and hepatic function markers levels while decreasing superoxide dismutase and glutathione peroxidase activity. Additionally, 5\u2010FU led to a notable increase in malondialdehyde content. However, MEL co\u2010administration to rats reversed most biochemical and histologic effects. In the control and MEL\u2009+\u20095\u2010FU groups, the values were comparable. The doses of MEL treatment had a significant positive impact on 5\u2010FU\u2010induced oxidative stress, apoptosis, lipid peroxidation and kidney damage. Our data concluded that MEL has an ameliorative effect on hepatorenal damage caused by 5\u2010FU.<\/jats:p>","DOI":"10.1111\/bcpt.13976","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T05:44:23Z","timestamp":1703223863000},"page":"397-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Therapeutic benefit of melatonin in 5\u2010fluorouracil\u2010induced renal and hepatic injury"],"prefix":"10.1111","volume":"134","author":[{"given":"Razieh","family":"Mansoori","sequence":"first","affiliation":[{"name":"Student Research Committee Babol University of Medical Sciences  Babol Iran"},{"name":"Department of Pharmacology and Toxicology, School of Medicine Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohrab","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology Research 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