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Patients diagnosed with CKD were divided into CKD without dialysis and CKD with dialysis. PGx prescription drugs were retrieved from the Patient Administration System. Actionable dosing guidelines (AG) for specific drug\u2013gene pairs for CYP2D6, CYP2C9, CYP2C19 and SLCO1B1 were retrieved from the PharmGKB homepage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 1241 individuals, 25.5% were on dialysis. The median number of medications for each patient was 9 within the non\u2010dialysis group and 16 within the dialysis group. Thirty\u2010one distinct PGx drugs were prescribed. Altogether, 76.0% (943 individuals) were prescribed at least one PGx drug and the prevalence of prescriptions of PGx drugs was higher in the dialysis group compared to the non\u2010dialysis group. The most frequently prescribed drugs with AG were metoprolol, pantoprazole, atorvastatin, simvastatin and warfarin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that a substantial proportion of patients with CKD are exposed to drugs or drug combinations for which there exists AG related to PGx of CYP2D6, CYP2C19, CYP2C9 and SLCO1B1.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcpt.13985","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T12:38:45Z","timestamp":1706963925000},"page":"531-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of drugs with pharmacogenomics (PGx)\u2010based dosing guidelines in a Danish cohort of persons with chronic kidney disease, both on dialysis and not on dialysis: Perspectives for prescribing optimization"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-8040","authenticated-orcid":false,"given":"Niels","family":"Westergaard","sequence":"first","affiliation":[{"name":"Centre for Nursing University College Absalon  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4058-3012","authenticated-orcid":false,"given":"Morten","family":"Baltzer Houlind","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"},{"name":"The Capital Region Pharmacy  Herlev Denmark"},{"name":"Department of Drug Design and Pharmacology University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lona Louring","family":"Christrup","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle Gybel","family":"Juul\u2010Larsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Strandhave","sequence":"additional","affiliation":[{"name":"Department of Nephrology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9365-1918","authenticated-orcid":false,"given":"Anne Estrup","family":"Olesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Clinical Pharmacology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2021.11.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/CKJ\/SFAB120"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u2010139X.2009.00629.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e328349c261"},{"key":"e_1_2_10_6_1","unstructured":"World Health Organization.Medication safety in polypharmacy: technical report. 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