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Besides benchmark negative control group, EAC model was constructed by intraperitoneal injection (i.p.) of 2.5\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> cells. Alongside positive control, two groups of EAC\u2010bearing mice received 100\u2009mg\/kg of CS and GF nanoparticles\/body weight daily for 14\u2009days. The kidney function was conducted by measuring urea, creatinine, ions, (anti)\/oxidative parameters and DNA damage. Also, measuring immunoreactivity of P53, proliferating cell nuclear antigen (PCNA), and B\u2010cell lymphoma 2 (Bcl\u20102) and apoptosis protein. The outcomes illustrated notable kidney toxicity, which indicated by elevations in urea, creatinine, oxidative stress, DNA damage and induction of apoptosis. These events were supported by the drastic alteration in kidney structure through histological examination. Administration of CS and GF nanoparticles was able to enhance the antioxidant power, which further reduced oxidative damage, DNA injury, and apoptosis. These results indicated the protective and therapeutic role of biogenic chitosan and maitake nanoparticles against nephrotoxicity.<\/jats:p>","DOI":"10.1111\/bcpt.13988","type":"journal-article","created":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T23:59:35Z","timestamp":1708300775000},"page":"472-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ehrlich ascites carcinoma provokes renal toxicity and DNA injury in mice: Therapeutic impact of chitosan and maitake nanoparticles"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3850-4258","authenticated-orcid":false,"given":"Hamed A.","family":"Abosharaf","sequence":"first","affiliation":[{"name":"Biochemistry Division, Chemistry Department, Faculty of Science Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa 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